Sökning: "therapeutic targets"

Visar resultat 1 - 5 av 252 avhandlingar innehållade orden therapeutic targets.

  1. 1. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Andrea Boman; Linköpings universitet.; Linköpings universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrospinal fluid CSF ; biomarkers; therapeutic targets; neurodegeneration; Alzheimer’s disease AD ; Parkinson’s disease PD ; Corticobasal degeneration CBD ; Progressive supraneuclear palsy PSP ; Lysosomes; Endosomes; Autophagy; LAMP-2; Lysozyme;

    Sammanfattning : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. LÄS MER

  2. 2. Novel therapeutic targets in pediatric neural tumors

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Författare :Jelena Milosevic; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The embryonal tumors neuroblastoma and medulloblastoma are two of the most common and deadliest tumors in childhood. Both are heterogeneous tumors that arise in the peripheral and central nervous system, respectively. LÄS MER

  3. 3. Androgen controlled regulatory systems in prostate cancer potential new therapeutic targets and prognostic markers

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Peter Hammarsten; Umeå universitet.; [2008]
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; prostate cancer; angiogenesis; human biopsy; androgen ablation; castration; prognostic marker; prognostic factor; growth control; VEGF; vascular endothelial growth factor; EGFR; epidermal growth factor receptor; pEGFR; phosphorylated EGFR; phosphorylated epidermal growth factor receptor; VETERINARY MEDICINE Pathology; VETERINÄRMEDICIN Patologi;

    Sammanfattning : BACKGROUND: Prostate cancer is by far the most common cancer among Swedish men. Some patients have an aggressive lethal disease, but the majority of affected men have long expected survival. Unfortunately, the diagnostic tools available are insufficient in predicting disease aggressiveness. Novel prognostic markers are therefore urgently needed. LÄS MER

  4. 4. Eicosanoids in cancer: new therapeutic targets in neuroblastoma

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Författare :Agnes Rasmuson; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer is one of the most common causes of death for both children and adults in developed countries. Neuroblastoma is a cancer of the sympathetic nervous system that affects infants and young children. Neuroblastoma tumors are the most common solid extracranial tumors in children and are also the most deadly. LÄS MER

  5. 5. Identification and validation of therapeutic targets in sarcoma models

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Wessen Maruwge; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In spite of the low incidence of sarcomas, they are highly aggressive tumors, with high metastatic potential, and resistance to both chemotherapy and radiotherapy, leaving surgery as the only treatment option. There is evidently an urgent need in identifying molecular targets and oncogenic pathways in sarcomas that can be used for the development and evaluation of drugs directed against these tumors. LÄS MER