Sökning: "Alzheimer’s disease AD"

Visar resultat 1 - 5 av 334 avhandlingar innehållade orden Alzheimer’s disease AD.

1. 1. Stress steroids as accelerators of Alzheimer's disease. : Effects of chronically elevated levels of allopregnanolone in transgenic AD models

   Författare :Sara Bengtsson; Mingde Wang; Torbjörn Bäckström; Maja Johansson; Caroline Graff; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; Alzheimer s disease; beta-amyloid; synaptophysin; chronic stress; Morris water maze; obstetrik och gynekologi; Obstetrics and Gynaecology; medicinsk farmakologi; Medical Pharmacology; Neurology; neurologi; Geriatrics; geriatrik; medical behavioral science; medicinsk beteendevetenskap;

   Sammanfattning : Background Alzheimer’s disease (AD) and dementia are devastating con­ditions not only for the affected patients but also for their families.  The economical costs for the society are tremendous. LÄS MER

3. 2. Remembering in Alzheimer's disease : utilization of cognitive support

   Författare :Agneta Herlitz; Lars-Göran Nilsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Dementia; Memory; Episodic memory; Semantic memory; Severity of dementia; Alzheimers sjukdom; demens; minne;

   Sammanfattning : The aim of the present doctoral thesis was to investigate the ability of patients with Alzheimer's disease (AD) to utilize cognitive support in order to improve episodic remembering. A review of previous research indicated that most studies have failed to find beneficial effects of encoding support on memory in AD patients. LÄS MER

4. 3. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes

   Författare :Catarina Moreira Pinho; Elzbieta Glaser; Paolo Bernardi; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s Disease; Mitochondria; Mitochondria-associated ER membranes; human Presequence Protease; Biochemistry; biokemi;

   Sammanfattning : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. LÄS MER

5. 4. Neuroinflammation in Alzheimer's disease : Focus on NF-κB and C/EBP transcription factors

   Författare :Veronica Ramberg; Kerstin Iverfeldt; Josep Saura; Stockholms universitet; []
   Nyckelord :Alzheimer’s disease; neuroinflammation; NF-κB; C EBP; apoptosis; caspases; FRET; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

   Sammanfattning : Alzheimer's disease (AD) is the most common form of dementia among elderly. The disease is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic neuroinflammation. LÄS MER

7. 5. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease

   Författare :Ann-Sofi Johansson; Lars Lannfelt; Frida Ekholm Pettersson; Pär Gellerfors; Tobias Hartmann; Uppsala universitet; []
   Nyckelord :Neurosciences; Amyloid-β; Neurotoxicity; Aggregation; Protofibrils; Alzheimer s disease; Neurovetenskap;

   Sammanfattning : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). LÄS MER