Sökning: "desensitization"

Visar resultat 11 - 15 av 42 avhandlingar innehållade ordet desensitization.

  1. 11. Modulation of AMPA glutamate receptor functions in primary neuronal cultures

    Författare :Gvido Cebers; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :glutamate; AMPA; cerebellar granule cells; cortical cells; cyclothiazide; AP-1; transcription factors; receptor desensitization; Ca2 ; neurotoxicity; 45Ca2 uptake; apoptosis; ischemia; muscarinic; carbachol;

    Sammanfattning : Primary neuronal cultures were used to investigate the properties of AMPA receptors and functional consequences of their activation, as well as AMPA receptor desensitization and possibilities for its modulation. We established the presence and spontaneous functional activity of AMPA receptors in cerebellar granule and cortical cell cultures. LÄS MER

  3. 12. Function of B2-adrenoceptors on alveolar macrophages

    Författare :Anita Zetterlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :A;

    Sammanfattning : B2-Agonists are very effective drugs for bronchodilatation, provide a rapid relief of symptoms in asthma, and are recommended as first line treatment, together with steroids. The relaxation of bronchial smooth muscles is a well-established effect of B-agonists, but their effects on inflammatory cells in the airways are less certain. LÄS MER

  4. 13. Patch-clamp studies of the GABAA receptor using microfluidic methods

    Författare :Maria Millingen; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channel; microfluidics; GABAA receptor;

    Sammanfattning : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. LÄS MER

  5. 14. Cardiovascular beta-adrenergic signaling : Maturation and programming effects of hypoxia in a chicken model

    Författare :Isa Lindgren; Jordi Altimiras; Eduardo Villamor; Laura Bennet; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : Despite the importance of β-adrenergic receptors (βARs) in cardiovascular disease, not much is known about how prenatal hypoxia effects βAR signaling in the postnatal animal. Thus, the aim of this thesis was to characterize the pre- and postnatal maturation of the cardiovascular βARs and the effects of chronic prenatal hypoxia on βAR signaling in the embryo and adult animal using the chicken as experimental model. LÄS MER

  7. 15. Regulation of Intracellular Calcium in Brown Adipocytes

    Författare :Shi-Jin Zhang; Lawrence C.H Wang; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; zoofysiologi; Zoological physiology;

    Sammanfattning : Intracellular Ca2+ is considered a primary regulator of cell function. In the present study, the control and the effects of intracellular Ca2+ in brown adipocytes have been investigated. Cytosolic Ca2+ levels ([Ca2+]i) are the resultant of the activity of Ca2+ transport systems. LÄS MER