Sökning: "desensitization"

Visar resultat 16 - 20 av 42 avhandlingar innehållade ordet desensitization.

  1. 16. Chemoattractant receptor signaling and neutrophil acctivation. Involvement of the cytoskeleton

    Författare :Huamei Fu; Göteborgs universitet; []
    Nyckelord :neutrophils; G-protein coupled receptors; signaling; cytoskeleton;

    Sammanfattning : Neutrophil granulocytes play a vital role in the host surveillance system and form the first line of defense against microbial infections. The migration of neutrophils to an infected/inflamed tissue is guided by chemoattractants released either from intruding microbes or from activated/damaged host cells. LÄS MER

  3. 17. Activation of professional phagocytes with emphasis on the formyl peptide receptor family

    Författare :Jennie Karlsson; Göteborgs universitet; []
    Nyckelord :phagocyte; G-protein coupled receptor; chemoattractant; formyl peptide receptor; reactive oxygen species; calcium;

    Sammanfattning : Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate immune system and play an important role in the battle against pathogens. G-protein coupled receptors (GPCRs) and more specifically chemoattractant receptors are a vital part in guiding phagocytes towards the site of infection. LÄS MER

  4. 18. GABA-, glycine- and glutamate-induced currents in rat medial preoptic neurons : functional interactions and modulation by capsaicin

    Författare :Urban Karlsson; Staffan Johansson; Johannes Krupp; Bryndis Birnir; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medial preoptic nucleus; synaptic transmission; glutamate; GABA; glycine; TRPV1; Physiology; Fysiologi;

    Sammanfattning : The medial preoptic nucleus (MPN) of the hypothalamus plays a major role in many functions involved in maintaining bodily homeostasis, such as thermoregulation and osmoregulation, as well as in the control of complex behaviours, e.g. sexual behaviour. LÄS MER

  5. 19. On Fever Mechanisms & Preoptic Signalling

    Författare :Anna Sundgren Andersson; Robert Dantzer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Sammanfattning : Fever, a 1-4 °C elevation of the body temperature, is part of the systemic inflammatory response to infection or tissue damage, and it is believed to be a potent host defence. The underlying physiological mechanisms of the febrile response are one of the two main objectives in this thesis, where studies conducted in whole animals (rats and mice), chiefly aimed at clarifying the cytokine cascade in fever. LÄS MER

  7. 20. Sex and stress steroid modulation of GABA mediated chloride ion flux in rat CNS

    Författare :Jessica Strömberg; Per Lundgren; Torbjörn Bäckström; David Haage; Esa Korpi; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; allopregnanolone; chloride ion uptake; patch-clamp; 3beta-steroids; kinetic parameters; rat brain; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Sammanfattning : Background: Sex and stress steroids are metabolized to 3a-hydroxy-pregnane-steroid metabolites such as allopregnanolone (Allo) and tetrahydrodeoxycorticosterone (THDOC). Allo and THDOC are neuroactive steroids that are metabolized in the brain and act in brain as potent positive GABAA receptor function modulators. LÄS MER