Sökning: "cytokeratin"

Visar resultat 1 - 5 av 37 avhandlingar innehållade ordet cytokeratin.

  1. 1. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking

    Författare :Stefan Broselid; Drug Target Discovery; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AKAP5; AKAP; MAGUK; cAMP signaling; constitutive signaling; signalosome; GPER; GPR30; GPCR; cytokeratin; RAMP3; apoptotic signaling; breast cancer; PDZ; PDZ-ligand;

    Sammanfattning : The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. LÄS MER

  3. 2. Ulcerative colitis : colorectal cancer risk and surveillance in an unselected population

    Författare :Jan Lindberg; Curt Tysk; Umeå universitet; []
    Nyckelord :ulcerative colitis; colonoscopic surveillance; colorectal cancer; dysplasia; DNA aneuploidy; cytokeratin; colorectal resection; early onset; Surgery; kirurgi;

    Sammanfattning : Ulcerative colitis is a chronic inflammatory disease that mainly affects the colon and rectum. Onset of disease is most common between the ages of 15-35 years. There is an observed increased risk of colorectal cancer associated with the disease. The risk is often described to be 2% after 10 years, 8% after 20 years and 18% after 30 years disease. LÄS MER

  4. 3. Strategies to improve cancer radioimmunotargeting

    Författare :Anders Ullén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : cancer; monoclonal antibody; antiidiotypic antibody; radioimmunotargeting; placental alkaline phosphatase; cytokeratin; BIAcore.;

    Sammanfattning : Radioimmunotherapy (RIT) and radioimmunolocalisation (RIL) are developing and promising technologies to diagnose and treat tumours by use of radiolabelled antibodies targeting tumour specific antigens. The major reason why RIL and RIT not are efficient enough, is the comparatively low accumulation of radiolabelled antibodies in the tumours. LÄS MER

  5. 4. Lung Metastases - Diagnostic, Prognostic and Molecular Aspects with Focus on Colorectal Cancer

    Författare :Halla Vidarsdottir; Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung cancer; lung metastasis; tissue microarray; TTF-1; napsin A; cytokeratin; GATA3; CDX2; PAX8; CRC; pulmonary metastasectomy; RBM3; recurrence; survival; NGS; Trusight tumor 26; Trusight Oncology 500;

    Sammanfattning : In Sweden 4200 patients are diagnosed with lung cancer and 6500 patients with colorectal cancer (CRC) annually. The lungs are a common site for metastases. Immunohistochemistry (IHC) is a helpful aid in diagnostics of a pulmonary tumour. LÄS MER

  7. 5. Monoclonal anti-cytokeratin antibodies and cytokeratin fragments as in vitro and in vivo tumour markers

    Författare :Åke Silén; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER