Sökning: "atherogenic diet"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden atherogenic diet.

1. 1. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease

   Författare :Lena Brånén; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; cell replication; Cardiovascular system; Kardiovaskulära systemet; spindle-shaped; epithelioid; smooth muscle cells; periadventitial cuff injury; sTNF-R1; bone marrow transplantation; chimeric fusion protein; atherogenic diet; ApoE; TNF-a; genetically altered mice; en face preparation; atherosclerosis; neointimal hyperplasia;

   Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER

3. 2. Cardiovascular risk factors, diet and the metabolic syndrome

   Författare :Per Sjögren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The clustering of metabolic disturbances, referred to as the metabolic syndrome, is today at the centre of attention. The rationale for this focus is that the prevalence of the metabolic syndrome is increasing globally with subsequent increased risk for cardiovascular complications. LÄS MER

4. 3. Cholesterol-lowering and anti-atherogenic effects of oats in mice

   Författare :Kristina E Andersson; Cellulär biomekanik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholesterol; Inflammation; Bile acids; Atherosclerosis; Oats; Beta-glucans;

   Sammanfattning : The cholesterol-lowering effect of oats is well established, but the crucial properties eliciting this effect need to be further investigated to optimize the use of oats as functional foods. Furthermore, there are almost no reports investigating the effect of oats on atherosclerosis development. LÄS MER

5. 4. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

   Författare :Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER

7. 5. The inflammatory response to arterial injury

   Författare :Paul Dimayuga; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; neointima; arterial injury; inflammation; Kardiovaskulära systemet;

   Sammanfattning : Atherosclerosis as a disease is postulated to stem from a response to injury of the arterial wall by various stimuli. The inflammatory response is proposed to mediate intimal formation after injury. One pathway of cellular response to injury is through transcription factor NF-kB. LÄS MER