Sökning: "apparent solubility"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden apparent solubility.

1. 1. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility

   Författare :Anita M. Persson; Curt Pettersson; Anders Sokolowski; Anders Karlsson; Alex Avdeef; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analytical methods; HPLC high-performance liquid chromatography ; miniaturization; in vitro dissolution rate; apparent solubility; physicochemical properties; dissolution media; correlation study; chemometrics; Pharmaceutical chemistry; Farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. LÄS MER

3. 2. Mercury immobilization : a requirement for permanent disposal of mercury waste in Sweden

   Författare :Margareta Svensson; Bert Allard; Anders Düker; Björn Öhlander; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mercury; mercury sulphide; cinnabar; stabilization; solidification; encapsulation; monolith leaching; solubility; mercury speciation; diffusion; apparent diffusion coefficient; Chemistry; Kemi; Enviromental Science; Miljövetenskap;

   Sammanfattning : The Swedish Government states that mercury in the Swedish industry and private use shall be collected and waste containing more than 1% of mercury shall be conditioned for permanent storage in proposed groundwater-saturated repository in deep bedrock. The owners of mercury waste in Sweden are responsible for finding ways to the conversion of the mercury waste to insoluble forms. LÄS MER

4. 3. Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica

   Författare :Xin Xia; Alfonso E. Garcia-Bennett; Xiaodong Zou; Göran Frenning; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mesoporous silica; drug delivery; solubility enhancement; active pharmaceutical ingredients; oral toxicity; confinement; crystallization; pharmaceutical excipients; bioavailability; Inorganic Chemistry; oorganisk kemi;

   Sammanfattning : Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. LÄS MER

5. 4. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

   Författare :Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. LÄS MER

7. 5. Mesoporous magnesium carbonate as a drug delivery vehicle for stabilising amorphous drugs and regulating their release rate

   Författare :Peng Zhang; Maria Strømme; Niklas Hedin; Uppsala universitet; []
   Nyckelord :mesoporous; magnesium carbonate; drug delivery; solubility enhancement; bioavailability; pharmacokinetics; diffusion release; controlled release; Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Engineering Science with specialization in Nanotechnology and Functional Materials;

   Sammanfattning : In today’s drug discovery, the number of candidate drugs based on new molecular entities with poor aqueous solubility is increasing. Since poor aqueous solubility of an active pharmaceutical ingredients (APIs) is associated with low bioavailability and thus limite their therapeutic effect, this is often a great challenge in the development of new drugs when oral administration is the preferred route of administration. LÄS MER