Sökning: "immunological synapse"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden immunological synapse.

  1. 1. Calmodulin mediated regulation of NF-kappaB in lymphocytes

    Författare :Sofia Edin; Thomas Grundström; Sam Okret; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium; CaM; CaMKII; NF-kappaB; Bc110; immunological synapse; Molecular biology; Molekylärbiologi;

    Sammanfattning : NF-κB transcription factors are regulators of a wide spectrum of genes involved in immune responses and inflammation as well as cellular proliferation and survival. Transcriptionally competent NF-κB dimers are retained in the cytoplasm of resting cells by binding to inhibitors of NF-κB (IκBs). LÄS MER

  3. 2. Modelling T helper cell activation and development

    Författare :Andreas Jansson; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; T cells; mathematical models; differentiation; computer simulation; mathematical models; cellular signal transduction; Bioinformatics; Bioinformatik; Natural sciences; Naturvetenskap; Technology; Teknik;

    Sammanfattning : T helper (Th) cell activation and development is one of the most critical events in regulating the adaptive immune response. Understanding its regulation could be of great therapeutical value as many severe diseases are associated with failure in controlling T cell activation and development. LÄS MER

  4. 3. Regulation of activation of NF-κB by Calmodulin in T-lymphocytes

    Författare :Sreenivasa Rao Oruganti; Thomas Grundström; Eva Sverinson; Umeå universitet; []
    Nyckelord :Calcium; Calmodulin; CaMKII; TCR; Bcl10; NF-κB;

    Sammanfattning : Nuclear factor kappa B (NF-kB) is a widely expressed family of transcription factors that are involved in a diverse number of processes. These include inflammation or differentiation, survival or apoptosis, and proliferation or cell cycle arrest. LÄS MER

  5. 4. Molecular mechanisms and complete antigen formation in allergic contact dermatitis

    Författare :Stefan Ahlfors; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypersensitivity; adduct; immune response.; Allergy; hapten;

    Sammanfattning : Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. LÄS MER

  7. 5. Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis

    Författare :Martha-Lena Müller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined how certain missense mutations in genes encoding syntaxin-11 and Munc18-2 abolish exocytosis and cause disease. LÄS MER