Sökning: "TET2"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet TET2.
1. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors
Sammanfattning : Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). LÄS MER
2. DNA methylation in T cell leukaemia
Sammanfattning : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. LÄS MER
3. Multi-omic time-series analysis of T-cells as a model for identification of biomarkers, treatments and upstream disease regulators
Sammanfattning : CD4+ T-cell function and their process of differentiation is a central piece of the puzzle in a multitude of diseases. CD4+ T-cells are part of the adaptive immune system and function by directing other immune cells to the site of infection and instructing B-cells to produce antibodies, among many other functions. LÄS MER
4. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations
Sammanfattning : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. LÄS MER
5. Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities
Sammanfattning : Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of normal blood cells. LÄS MER