Sökning: "clonal evolution"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden clonal evolution.

  1. 1. Mitochondria and Human Evolution

    Författare :Max Ingman; Ulf Gyllensten; Peter Underhill; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mitochondria; hominidae; human evolution; population genetics; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

    Sammanfattning : Mitochondrial DNA (mtDNA) has been a potent tool in studies of the evolution of modern humans, human migrations and the dynamics of human populations over time. The popularity of this cytoplasmic genome has largely been due to its clonal inheritance (in Man) allowing the tracing of a direct genetic line. LÄS MER

  3. 2. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias

    Författare :Jonathan Lindström; Ran Friedman; Arne Traulsen; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukaemia; Stochastic modelling; Tyrosine kinase inhibitor; Drug resistance; Clonal evolution; Biomedical Sciences; Biomedicinsk vetenskap; Medicinsk kemi; Medical Chemistry;

    Sammanfattning : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. LÄS MER

  4. 3. Genomic Diversity and Evolution of Parasitism in Nematode-trapping Fungi

    Författare :Dag Ahrén; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ecology; nematode-trapping fungi; expressed sequence tags; functional genomics; bioinformatics; parasitism; Genomic diversity; Evolution; Ekologi; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Nematode-trapping fungi are soil-living organisms that have the ability to form infection structures, traps to capture nematodes. Many nematode species are parasites on plants and animals, which have resulted in an interest to use the nematode-trapping fungi as biological control agents. LÄS MER

  5. 4. Physiological integration and morphological plasticity in extensive clonal plants

    Författare :Tina D'Hertefeldt; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant ecology; Maianthemum; Carex; Clonal plants; tracers; Växtekologi;

    Sammanfattning : Clonal plants show a large variation in physiological integration, i.e. the translocation of resources among ramets within the clone. LÄS MER

  7. 5. Molecular and Genetic Evidence for Antigen Selection in the Pathogenesis of Chronic Lymphocytic Leukemia

    Författare :Lesley Ann Sutton; Richard Rosenquist; John Gribben; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGHV4-34; microenvironment; stereotypy; immunoglobulin; intraclonal diversification; clonal evolution;

    Sammanfattning : Antigens play a critical role in the development of chronic lymphocytic leukemia (CLL) by binding to and stimulating leukemic precursor cells at some point during CLL ontogeny. Nevertheless, much remains unknown and further studies are necessary before an accurate model of antigen-drive can be ascertained. LÄS MER