Sökning: "Secondary Ion Mass Spectrometry Imaging"
Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Secondary Ion Mass Spectrometry Imaging.
1. Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired amyloid-positive (CU-AP) individuals, but these Aβ plaques are primarily diffuse in structure. LÄS MER
2. Label free analysis and spatial distribution of molecular lipids in brain tissue and cells using mass spectrometry imaging
Sammanfattning : Lipids are important inherent components in brain and cell membranes, which play significant biological roles in cell function. Identification and localization of specific biomolecules such as peptides and lipids within cellular membranes is currently a major challenge in metabolomics and biological studies. LÄS MER
3. Mass spectrometry of biopolymers based on ion-induced desorption
Sammanfattning : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. LÄS MER
4. Molecular and epidemiological studies on eyes with pseudoexfoliation syndrome
Sammanfattning : Pseudoexfoliation (PEX) syndrome is an age-related condition characterized by the production and accumulation of extracellular fibrillary material in the anterior segment of the eye. PEX predisposes for several pathological conditions, such as glaucoma and complications during and after cataract surgery. LÄS MER
5. Imaging mass spectrometry for in situ lipidomics: from cell structures to cardiac tissue
Sammanfattning : Imaging of cells and tissues is important for studying different processes within biological systems due to the spatial information provided for different molecular species during imaging. One powerful imaging technique is mass spectrometry imaging (MSI). LÄS MER