Sökning: "time of flight secondary ion mass spectrometry"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden time of flight secondary ion mass spectrometry.

1. 1. Mass spectrometry of biopolymers based on ion-induced desorption

   Författare :Roman Alexandrovich Zubarev; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Strålningsvetenskap; Radiation biology; Strålningsbiologi; Ion Physics; jonfysik;

   Sammanfattning : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. LÄS MER

3. 2. Molecular and epidemiological studies on eyes with pseudoexfoliation syndrome

   Författare :Amelie Botling Taube; Jonas Bergquist; Albert Alm; Eva Larsson; Hannu Uusitalo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseduoexfoliation syndrome; PEX; aqueous humor; cataract; cataract surgery; lens capsule; proteomics; mass spectrometry; MS; MALDI TOF MS MS; quantitative proteomics; iTRAQ; dimethyl labeling; imaging mass spectrometry; IMS; time of flight secondary ion mass spectrometry; TOF-SIMS; crystallin; epidemiology; risk factor; Ophtalmology; Oftalmiatrik;

   Sammanfattning : Pseudoexfoliation (PEX) syndrome is an age-related condition characterized by the production and accumulation of extracellular fibrillary material in the anterior segment of the eye. PEX predisposes for several pathological conditions, such as glaucoma and complications during and after cataract surgery. LÄS MER

4. 3. Imaging of lipids and proteins in Alzheimer's disease using Time-of-Flight Secondary Ion Mass Spectrometry

   Författare :Louise M Carlred; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QCM-D; fluorescence microscopy; ToF-SIMS; Amyloid-β; immunohistochemistry; Sulfatides; antibodies; liposomes; Alzheimer’s disease; Cholesterol;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the formation of senile plaques. These plaques, which consist of aggregations of a peptide called amyloid-β, are deposited in-between the nerve cells in the brain, where they disrupt the signaling processes. LÄS MER

5. 4. Development and Application of ToF-SIMS for Clinical and Microbiological Analysis

   Författare :Kelly Dimovska Nilsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; Imaging mass spectrometry; Antibiotic resistance; Basal cell carcinoma; Gas cluster ion beam; GCIB; Time-of-flight secondary ion mass spectrometry; BCC; Escherichia coli; E. coli; FabF; DapF; Lpp; Lipid A; ECAcyc; Depth profile;

   Sammanfattning : The aim of the work of this thesis was to further the implementation of timeof-flight secondary ion mass spectrometry (ToF-SIMS) in biological analysis and to generate new knowledge from the samples analysed. ToF-SIMS is a chemical analysis technique. LÄS MER

7. 5. Analysis of phospholipids in cellular membranes with LC and imaging mass spectrometry

   Författare :Ingela Lanekoff; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; TOF-SIMS; Phospholipid; Cells; Anammox;

   Sammanfattning : Imaging mass spectrometry enables the creation of molecule specific images from the surface of a solid sample in vacuum. To solve the issue of bringing single cells into vacuum without altering their native distribution of molecules, a freeze fracture device that fits the time of flight secondary ion mass spectrometry (TOF-SIMS) IV instrument has been developed. LÄS MER