Sökning: "SH2"

Visar resultat 6 - 10 av 30 avhandlingar innehållade ordet SH2.

  1. 6. The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

    Författare :Kristina Holmqvist; Michael Welsh; Eva Degerman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Shb; Src; FAK; Angiogenesis; VEGFR-2; FGFR-1; Endothelial cells; Spreading; Stress fiber formation; siRNA; VEGF; FGF; Differentiation; Migration; Tube formation; RNAi; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. LÄS MER

  3. 7. Shb and Its Homologues: Signaling in T Lymphocytes and Fibroblasts

    Författare :Cecilia Lindholm; Hamid Band; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Shb; T cell receptor; IL-2 receptor; PDGF receptor; cell signaling; adapter proteins; LAT; Vav; PLC-g1; SLP-76; JAK1; JAK3; Jurkat cells; T cells; NK cells; Apoptosis.; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Stimulation of the T cell receptor (TCR) induces tyrosine phosphorylation of numerous intracellular proteins, leading to activation of the interleukin-2 (IL-2) gene in T lymphocytes. Shb is a ubiquitously expressed adapter protein, with the ability to associate with the T cell receptor and several signaling proteins in T cells, including: the TCR ζ-chain, LAT, PLC-γ1, Vav, SLP-76 and Gads. LÄS MER

  4. 8. Investigations of the breakup dynamics of small molecular ions recombining with electrons

    Författare :Fredrik Hellberg; Mats Larsson; Robert Continetti; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular physics; Molekylfysik;

    Sammanfattning : Dissociative recombination is the process in which a molecular ion recombines with an electron and then fragments into neutral products. This process has been studied in many experiments over the years at the ion storage ring CRYRING at the Manne Siegbahn Laboratory, Stockholm University. LÄS MER

  5. 9. The Role of the SHB Adapter Protein in Cell Differentiation and Development

    Författare :Vitezslav Kriz; Michael Welsh; Urban Lendahl; Uppsala universitet; []
    Nyckelord :Cell biology; SHB; transgene; ES cells; cavitation; knockout; mouse; vasculogenesis; hematopoiesis; endoderm; mesoderm; malformation; Cellbiologi;

    Sammanfattning : The present study was conducted in order to assess a role of the SH2 domain-containing adapter protein SHB in development and cell differentiation.Embryonic stem (ES) cells overexpressing SHB and SHB with an inactive SH2 domain (R522K-SHB) were obtained. LÄS MER

  7. 10. Shedding light on the STAT3 small molecule inhibitor field

    Författare :Sander Busker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. LÄS MER