Sökning: "SH2"

Visar resultat 16 - 20 av 30 avhandlingar innehållade ordet SH2.

  1. 16. Amino acid sequence and side chain specific synthetic receptors targeting protein phosphorylation

    Författare :Anil Incel; Frank Kjeldsen; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; imprinted polymers; synthetic receptors; PTM; phosphorylation; enrichment; diagnosis;

    Sammanfattning : Antibodies have become a critical component of many diagnostic assays and are used for therapeutic purposes. Nevertheless they often fail to meet the strict performance demands raised in industry and in the clinic (e.g. stability, reproducibility, selectivity, affinity). LÄS MER

  3. 17. Genome-wide identification of Grainy head target genes and their functions in Drosophila embryos

    Författare :Liqun Yao; Christos Samakovlis; Ruth Palmer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Grainy head; Stitcher; Vvl; wound healing; Tracheal development; Drosophila; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : The transcription factor Grainy head (Grh) is conserved from Drosophila to humans. Drosophila Grh plays important roles in epithelial differentiation and regeneration. LÄS MER

  4. 18. Specific signaling through heteromeric PDGF receptor complexes

    Författare :Simon Ekman; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. LÄS MER

  5. 19. CD47–SIRPα : an interaction of importance for bone cell differentiation

    Författare :Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

    Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER

  7. 20. Translational studies on acute myeloid leukemia focus on the receptor tyrosine kinase FLT3

    Författare :Alissa Marhäll; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; AML; FLT3;

    Sammanfattning : Among adults, acute myeloid leukemia (AML) is the second most frequent type of leukemia. In spite of recent improvements in the treatment of this disease, a majority of patients develop drug resistance, leading to poor overall survival. One of the factors behind this is mutations in the tyrosine kinase receptor (FLT3). LÄS MER