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Visar resultat 1 - 5 av 30 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Quantum Chemical Studies of Radical Cation Rearrangement, Radical Carbonylation, and Homolytic Substitution Reactions

    Författare :Daniel Norberg; Nessima Salhi-Benachenhou; Sten Lunell; Tim Clark; Uppsala universitet; []
    Nyckelord :Quantum chemistry; quantum chemistry; coupled-cluster; density functional theory; meta-GGA; reaction mechanism; potential energy surface; isomerization; fragmentation; dissociation; condensation; addition; SH2; hydrogen abstraction; iodine atom transfer; complex; weakly interacting system; hyperfine coupling constant; Kvantkemi;

    Sammanfattning : Quantum chemical calculations have been performed to investigate radical cation rearrangement, radical carbonylation, and homolytic substitution reactions of organic molecules. The rearrangement of the bicyclopropylidiene radical cation to the tetramethyleneethane radical cation is predicted to proceed with stepwise disrotatory opening of the two rings. LÄS MER

  3. 2. Molecular biology of Brouton's tyrosine kinase

    Författare :Carl-Magnus Bäckesjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-linked agammaglobulinemia; XLA; Bruton s tyrosine kinase; Btk; signal transduction; phosphorylation; pleckstrin homology domain; PH; SH2; SH3.;

    Sammanfattning : X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton s tyrosine kinase (Btk), a cytoplasmic enzyme related to the Src family of kinases. LÄS MER

  4. 3. Characterization and modelling of CEACAM1 interactions in cell signalling

    Författare :Kristmundur Sigmundsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : CEACAM1, the primordial carcino-embryonic Ag gene family member, is a transmembrane cell adhesion molecule expressed in leukocytes, epithelia, and blood vessel endothelia. As a result of differential splicing, CEACAM1 occurs as several isoforms, the two major ones being CEACAM1-L and -S, that have long (L) or short (S) cytoplasmic domains, respectively. LÄS MER

  5. 4. Signal transduction pathways involved in PDGF receptor-induced cellular responses

    Författare :Roya Hooshmand-Rad; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Platelet-derived growth factor (PDGF), is a potent connective tissue cell mitogen and chemoattractant which binds to two structurally related receptors denoted PDGF α- and β- receptors. Upon binding of PDGF to the receptor, signaling molecules containing Src Homology 2 (SH2) domains are recruited to the activated receptor and mediate propagation of the signal. LÄS MER

  7. 5. Biochemical and Structural Studies on the Adaptor Protein p130Cas

    Författare :Fariborz Nasertorabi; Kathryn R Ely; Lars Liljas; Jyrki Heino; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Integrin signaling; p130Cas; X-ray Crystallography; NMR Spectroscopy; Protein phosphorylation; BCAR-1; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Crk associated substrate (Cas) is an adaptor protein that becomes phosphorylated upon integrin signaling and influences regulation of cell processes such as migration, proliferation and survival. It consists of multiple domains and regions that can interact with several signaling proteins involved in different signaling pathways. LÄS MER