Sökning: "PODXL"

Hittade 5 avhandlingar innehållade ordet PODXL.

  1. 1. A valuable pair - candidate biomarkers RBM3 and PODXL in urothelial bladder cancer

    Författare :Karolina Granfelt Boman; Tumörmikromiljö; []
    Nyckelord :urothelial bladder cancer; RBM3; PODXL; Prognostic biomarker; Predictive biomarker; immunohistochemistry; tissue microarray TMA ;

    Sammanfattning : Abstract: Bladder cancer is a heterogenous disease, ranging from minimally invasive, low-grade tumours with lowrecurrence rates and mortality on one end of the spectrum, and muscle invasive, high-grade disease prone torecurrence, progression and death at the other end.The aim of this thesis was to investigate the expression, clinicopathological correlates and prognostic significanceof the candidate biomarkers podocalyxin-like protein (PODXL, papers II and III) and RNA-binding motif protein 3(RBM3, papers I, III and IV) in urothelial bladder cancer (UBC). LÄS MER

  3. 2. Towards improved oncological treatment of esophageal and gastric cancer. Clinical and translational studies

    Författare :David Borg; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal adenocarcinoma; Gastric cancer; PODXL; Prognosis; Prediction; Chemotherapy dose intensity; Dysphagia; Radiotherapy;

    Sammanfattning : BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. LÄS MER

  4. 3. Discovery and validation of podocalyxin-like protein as a prognostic biomarker in colorectal cancer

    Författare :Anna H Larsson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Colorectal cancer (CRC) is the third most common cancer worldwide with more than 700,000 deaths every year. Prognosis mostly depends on disease stage at diagnosis, however, outcome may vary considerably even within the same stage. LÄS MER

  5. 4. Biomarkers in pancreatic and other periampullary cancers - some familiar and one new

    Författare :Margareta Heby; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Periampullary adenocarcinoma; Pancreatic cancer; Biomarkers; Immunohistochemistry; Tissue microarrays;

    Sammanfattning : AbstractBackground: Adenocarcinomas arising in the area around the papilla of Vater are referred to as periampullary adenocarcinomas and are of four different anatomical origins: pancreas, distal bile duct, ampulla and duodenum. These heterogeneous tumors are usually divided into two morphological subtypes, pancreatobiliary type (PB-type) and intestinal type (I-type), which provides more important prognostic information than tumor origin. LÄS MER

  7. 5. Investigating the role of neural stem/progenitor regulators in the context of brain tumor development

    Författare :Isabelle Leefa Chong San; Stamcellscentrum (SCC); []
    Nyckelord :neural stem progenitor cells; regulators; brain tumor; cell of origin; cancer mechanisms;

    Sammanfattning : Adult neural stem/progenitor cells (NSPs) are multipotent and self-renew over an extensive period of time. Transformation events in such cells, such as genetic or epigenetic alterations can result in brain tumors. LÄS MER