Sökning: "PCP complex"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden PCP complex.

  1. 6. On the role of forebrain cholinergic innervation for phencyclidine-induced behaviors and gene expression patterns

    Författare :Sophia Savage; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The basalo-cortical cholinergic innervation reaches neural targets in cortex cerebri where it modulates the incoming sensory information, regulating arousal, attention, vigilance, memory and cognition. Progressive de generation of the cholinergic neurons in the basal forebrain is considered a hallmark of Alzheimer ’s disease related to cognitive impairment in this condition. LÄS MER

  2. 7. Influenza A virus infection and NMDA receptor function : a behavioral and molecular study of relevance for schizophrenia

    Författare :Simret Beraki; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; Influenza A virus; NMDA receptor; glutamate; cognition; learning; memory; hippocampus; water maze; mice; emotional; social interaction; gene expression; brain; behavior; phencyclidine; elevated plus-maze;

    Sammanfattning : Schizophrenia is a neuropsychiatric disorder characterized by positive and negative symptoms, as well as cognitive dysfunctions. There is no single cause of schizophrenia, instead complex combinations of genetic and environmental factors may contribute to the disorder, including exposure to viral infections or other environmental insults during early life. LÄS MER

  3. 8. Metallacyclic Phosphine Complexes and Intramolecular Csp3-H Bond Activation -Synthesis, Characterisation and Catalytic Application

    Författare :Sven Sjövall; Kemiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; catalysis; Heck; diphosphite; diphosphine; phosphine; cyclometallation; C-C activation; C-O activation; C-H activation; palladium; rhodium; iridium; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : The work presented in this thesis deals with metallacyclic late transition metal complexes, obtained by intramolecular Csp3-H activation, and the application of such compounds in catalysis. The new hemilabile P,O phosphines N-methyl-N-propionyl-2-(diphenylphosphino)benzylamine (DPPAM), o-(diphenylphosphino)benzoic acid ethyl ester (DPPES), o-(diphenylphosphino)benzoic acid methyl ether (DPPET) and ±-1-(2- diphenylphosphino)phenylethyl propionate (±-DPPMES) and the symmetrical diphosphorus donor ligands cis-1,3-bis[(diphenylphosphino)methyl]-cyclohexane (DPCY), cis-1,3-bis[(di-tertbutylphosphino)methyl]cyclohexane (DTBCY) and cis-1,3-bis[(di-isopropylphosphino)methyl]cyclohexane (DIPCY) have been synthesised, allowing the preparation of a range of new metallacyclic rhodium(III), iridium(III) and palladium(II) complexes. LÄS MER

  4. 9. Mechanistic investigation of platinum and palladium catalysed cross- coupling reactions. Implications for the Stille and Heck reactions

    Författare :Patrik Nilsson; Kemiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metallorganisk kemi; Organometallic chemistry; Oorganisk kemi; Inorganic chemistry; parameter fitting; numerical solutions; platinum II ; palladium II ; NMR spectroscopy; transmetallation; Heck; Stille; kinetics; mechanism;

    Sammanfattning : The present thesis deals with various types of palladium(II) and platinum(II) complexes and their use in homogeneous catalysis. The focus has been devoted to mechanistic investigations concerning the Stille and Heck reactions and studies under both catalytic and stoichiometric conditions were conducted. LÄS MER

  5. 10. Association of hydrophobic organic compounds to organic material in the soil system

    Författare :Silviu-Laurentiu Badea; Mats Tysklind; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HOCs; Organic Matter; Clay; DOM; Environmental Science; miljövetenskap;

    Sammanfattning : Contaminated soils and sediments have been identified as significant secondary sources of organic contaminants.  Leaching tests may be useful tools to estimate the mobility of contaminants via the water phase and thereby the risk for groundwater and surface water contamination. LÄS MER