Sökning: "elevated plus-maze"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden elevated plus-maze.

1. 1. Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat

   Författare :Julia Morud; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abstinence; Dopamine; Elevated plus-maze; GABA; Inhibitory control; Nicotine; Nucleus accumbens; Sensitization;

   Sammanfattning : Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. LÄS MER

3. 2. Nicotine sensitization and loss of inhibitory control. Role of serotonin

   Författare :Peter Olausson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nicotine; Amphetamine; Locomotor activity; Inhibitory control; Dopamine; Serotonin; Sensitization; Nucleus accumbens; Elevated plus-maze;

   Sammanfattning : Drug dependence is a devastating disorder present in all parts of the world. It is manifested by craving and a general loss of control over the drug intake and the life situation, ultimately leading to compulsive use of the addictive drug at the expense of normal behavioral patterns. LÄS MER

4. 3. Maternal Separation in Rats : An Experimental Model for Long-Term Effects of Early Life Experiences on Neurochemistry, Voluntary Ethanol Intake and Exploration and Risk Assessment Behavior

   Författare :Erika Roman; Ingrid Nylander; J. Dee Higley; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Handling; Maternal Deprivation; Environment; Opioids; Dopamine; Alcohol; Stress; Concentric Square Field; Open Field; Elevated Plus-maze; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

   Sammanfattning : The period of early life is important for the development of individual brain function and behavior. Human studies have shown altered vulnerability to develop psychopathology and/or excessive drug intake, possibly leading to dependence, as a consequence of early life experiences. LÄS MER

5. 4. Influenza A virus infection and NMDA receptor function : a behavioral and molecular study of relevance for schizophrenia

   Författare :Simret Beraki; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Schizophrenia; Influenza A virus; NMDA receptor; glutamate; cognition; learning; memory; hippocampus; water maze; mice; emotional; social interaction; gene expression; brain; behavior; phencyclidine; elevated plus-maze;

   Sammanfattning : Schizophrenia is a neuropsychiatric disorder characterized by positive and negative symptoms, as well as cognitive dysfunctions. There is no single cause of schizophrenia, instead complex combinations of genetic and environmental factors may contribute to the disorder, including exposure to viral infections or other environmental insults during early life. LÄS MER

7. 5. Central neuropeptide Y (NPH) expression and function : role in stress, experimental anxiety, and cognition

   Författare :Annika Thorsell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neuropeptide Y; stress; experimental anxiety; cognition; lipid-mediated gene transfer; transgenic animals; rat;

   Sammanfattning : Neuropeptide Y (NPY), a 36 amino acid peptide abundantly expressed throughout the mammalian nervous system, has been implicated in experimental anxiety and stress related responses, feeding, and learning and memory. These functions are mediated via different receptor subtype populations (Y1-Y6), all belonging to the G-protein coupled receptor superfamily. LÄS MER