Sökning: "Michael Knopp"

Hittade 2 avhandlingar innehållade orden Michael Knopp.

1. 1. Mechanisms of Antibiotic Resistance Evolution

   Författare :Michael Knopp; Dan Andersson; Anca Segall; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution;

   Sammanfattning : The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems. The development of new antibiotics is slow and cannot counterbalance the dissemination of resistant bacteria. LÄS MER

3. 2. Degradation, Metabolism and Relaxation Properties of Iron Oxide Particles for Magnetic Resonance Imaging

   Författare :Karen Briley Saebo; Håkan Ahlström; Atle Bjørnerud; Michael Knopp; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; Magnetic Resonance Imaging; contrast agents; iron oxide particles; metabolism; relaxation mechanisms; Radiologisk forskning; Radiological research; Radiologisk forskning;

   Sammanfattning : Whereas the effect of size and coating material on the pharmacokinetics and biodistribution of iron oxide based contrast agents are well documented, the effect of these parameters on liver metabolism has never been investigated. The primary purpose of this work was to evaluate the effect of iron oxide particle size and coating on the rate of liver clearance and particle degradation using a rat model. LÄS MER