Sökning: "Matrix-Assisted Laser Desorption Ionization Mass Spectrometry"

Visar resultat 21 - 25 av 50 avhandlingar innehållade orden Matrix-Assisted Laser Desorption Ionization Mass Spectrometry.

1. 21. Sample preparation and mass spectrometry in proteome studies

   Författare :Daniel Hirschberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Proteome studies aim to link gene to function. Instead of screening for function in a specific protein as in classical protein chemistry, proteins are now screened against a specific phenotype, disease or metabolic state. LÄS MER

3. 22. Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease

   Författare :Ibrahim Kaya; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Lipids; Amyloid plaques; Mass spectrometry imaging; MALDI; Trimodal MALDI; Static MALDI; Dual polarity MALDI-MSI on the same pixel points; Neurodegeneration; Immunopathology; Amyloid peptides; APOE; Myelin; Sulfatides; 5xFAD; tgSwe; tgArcSwe; APP;

   Sammanfattning : Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. LÄS MER

4. 23. Microfluidic electrocapture in proteomic sample preparation for mass spectrometry

   Författare :Susanne Vollmer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Proteomics is a technology-driven discipline and very labor-intensive. Over the last couple of years, methods with microfluidic systems have been used to simplify analytical procedures via integration of laboratory processes and equipment into miniaturized formats to achieve reproducible and high throughput analyses of biomolecules. LÄS MER

5. 24. On chip integrated sample preparation for proteomics

   Författare :Simon Ekström; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Elektroteknik; Electrical engineering; enzymologi; Proteiner; enzymology; Proteins; Analytisk kemi; sample preparation; mass spectrometry; microfluidics; miniaturization; Biochemical technology; proteomics; Analytical chemistry; Biokemisk teknik;

   Sammanfattning : The aim of this thesis project has been to create miniaturized analytical tools that improve sample preparation for the very rapidly growing field of proteomics research. The presented miniaturized analytical tools provide novel and generic analytical solutions, which are highly adaptable for analysis of various low abundant biomolecules. LÄS MER

7. 25. Methods for protein analysis by capillary electrophoresis and mass spectrometry

   Författare :Joakim Romson; Åsa Emmer; Peter Dinér; Lukas Käll; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MALDI; Concentration plates; Alkyl ketene dimer; CE-MALDI-MS2; On-target digestion; Automation; Robot; Pieris napi; spermatophore; ESI-MS2; Osteopontin; MALDI; Koncentrationsprovplatta; alkylketenedimer; CE-MALDI-MS2; enzymklyvning på provplatta; Automatisering; Robot; Pieris napi; Spermatofor; ESI-MS2; Osteopontin; Kemi; Chemistry;

   Sammanfattning : Protein analysis is important to understanding biological systems, but sample diversity necessitates a multitude of analysis techniques and methods. Challenges that are addressed include analysis of low abundance samples, fractionation to reduce sample complexity, and automation to reduce time and cost. LÄS MER