Sökning: "MALDI"

Visar resultat 1 - 5 av 123 avhandlingar innehållade ordet MALDI.

  1. 1. Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease

    Författare :Ibrahim Kaya; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Lipids; Amyloid plaques; Mass spectrometry imaging; MALDI; Trimodal MALDI; Static MALDI; Dual polarity MALDI-MSI on the same pixel points; Neurodegeneration; Immunopathology; Amyloid peptides; APOE; Myelin; Sulfatides; 5xFAD; tgSwe; tgArcSwe; APP;

    Sammanfattning : Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. LÄS MER

  3. 2. Improved mass accuracy in MALDI-TOF-MS analysis

    Författare :Martin Kempka; Johan Roeraade; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; MALDI; mass spectrometry; mass accuracy; peak picking; ion formation; proteins; peptides; chip; sample handling; sensitivity.; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Mass spectrometry (MS) is an important tool in analytical chemistry today, particularly in the field of proteomics where identification of proteins is the central activity. The focus in this thesis has been to improve the mass accuracy of MS-analyses in order to improve the possibility for unambiguous identification of proteins. LÄS MER

  4. 3. Sample preconcentration in open microchannels : Combinations with MALDI and nano-ESI mass spectrometry and computer simulations

    Författare :Saara Mikkonen; Åsa Emmer; Leopold Ilag; Jenny Ottosson Takanen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Preconcentration; open microchannel; microchip; MALDI; electrospray ionization; nanoelectrospray; mass spectrometry; computer simulation;

    Sammanfattning : In this thesis a novel concept for preconcentration of biomolecules in open microchannels is presented. The preconcentration is based on electromigration of charged analytes, and detection is performed with matrix-assisted laser desorption/ionization (MALDI) or nano-electrospray ionization (nESI) mass spectrometry (MS). LÄS MER

  5. 4. Mass spectrometric studies of cellulose ethers

    Författare :Dane Momcilovic; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymerteknik; biopolymers; Polymer technology; Analytisk kemi; Analytical chemistry; enzymatic depolymerisation; reductive amination; electrospray ionisation; cellulose ethers; MALDI; mass spectrometry;

    Sammanfattning : Cellulose based derivatives, such as cellulose ethers, today find many applications in a diverse range of fields. The numerous applications put high demands on the technological performance of the cellulose ethers. LÄS MER

  7. 5. New Mass Spectrometric Methods for Structure Analysis of Carboxymethyl Cellulose

    Författare :Jonas Enebro; Sigbritt Karlsson; Dane Momcilovic; Ulf Germgård; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carboxymethyl cellulose; substituent distribution; rheology; enzyme hydrolysis; cellulase; permethylation; liquid chromatography; MALDI; ESI; mass spectrometry; Polymer chemistry; Polymerkemi;

    Sammanfattning : Carboxymethyl cellulose (CMC) is a cellulose derivative, made from cellulose by introduction of carboxymethyl groups along the molecules. The properties of CMC are affected by several parameters where the molar mass and molar mass distribution, degree of substitution (DS) and the distribution pattern along, and between, the cellulose molecules are the most prominent. LÄS MER