Sökning: "In-vitro simulations"

Visar resultat 6 - 10 av 57 avhandlingar innehållade orden In-vitro simulations.

  1. 6. In-silico design of peptide-based transfection systems, in-vitro validation, and up-take pathways investigation

    Författare :Moataz Dowaidar; Ülo Langel; IngMarie Nilsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; QSAR; PepFect; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Cell-penetrating peptide-based transfection systems (PBTS) are a promising group of drug delivery vectors. Cell-penetrating peptides (CPPs) are short cationic peptides that are able of transporting cell non-permeant cargos into different cell types. LÄS MER

  3. 7. High-Tc SQUIDs for magnetophysiology - development of a magnetometer system and measurements of evoked fields from hippocampal neurons in vitro

    Författare :Per Magnelind; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuromagnetism; brain slice; neurophysiology; electrophysiology; hippocampus; biomagnetism; SQUID;

    Sammanfattning : This thesis concerns development of a system based on a high-transition-temperature superconducting quantum interference device (high-Tc SQUID) magnetometer. The system has been designed and used for magnetic field recordings from brain slices, i.e. magnetophysiology. LÄS MER

  4. 8. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    Författare :Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. LÄS MER

  5. 9. Molecular-dynamics simulations of polymeric surfaces for biomolecular applications

    Författare :Stela Andrea Muntean; M.A.J. Michels; M.W.J. Prins; A.V. Lyulin; Technische Universiteit Eindhoven; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polystyrenes; Molecular Dynamics; Computer Simulation; Water; Molecules; Atoms; Hydrophilicity; Biosensors; Myoglobin; Physics; Fysik;

    Sammanfattning : In-vitro diagnostics plays a very important role in the present healthcare system. It consists of a large variety of medical devices designed to diagnose a medical condition by measuring a target molecule in a sample, such as blood or urine. LÄS MER

  7. 10. Understanding structural features of biomolecular interactions : from classical simulations to ab initio calculations

    Författare :Yossa Dwi Hartono; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The structures of biomolecules and their interactions dictate their functions. In this thesis, five papers are presented to illustrate how the dynamics of biomolecules can be investigated and derivation of desired thermodynamic quantities obtained by utilising a diverse range of computational techniques, from simulations utilising classical mechanical descriptions to calculations employing quantum mechanical descriptions. LÄS MER