Sökning: "In-vitro simulations"

Visar resultat 11 - 15 av 57 avhandlingar innehållade orden In-vitro simulations.

  1. 11. In silico Identification of Thyroid Disrupting Chemicals : among industrial chemicals and household dust contaminants

    Författare :Jin Zhang; Patrik Andersson; A. Elisabeth Sauer-Eriksson; Liang-Hong Guo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thyroid disruption chemicals; virtual screening; tranthyretin; thyroid hormone receptor; QSAR modeling; molecular docking; molecular dynamics;

    Sammanfattning : Thyroid disruptions by xenobiotics have been associated with a broad spectrum of severe adverse human health effects, such as impaired brain development and metabolic syndrome. Ingestion of indoor dust and contact with industrial chemicals are two significant human exposure routes of thyroid hormone disrupting chemicals (THDCs), raising serious concerns for human health. LÄS MER

  3. 12. Modeling and Data Analysis in Cellular Biophysics

    Författare :Jacob Kowalewski; Hjalmar Brismar; Anita Aperia; Björn Önfelt; Karl-Eric Magnusson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik;

    Sammanfattning : Cellular biophysics deals with the physical aspects of cell biology. This thesis presents a number of studies where mathematical models and data analysis can increase our understanding of this field. LÄS MER

  4. 13. Machine Learning Based Analysis of DNA Methylation Patterns in Pediatric Acute Leukemia

    Författare :Christofer Bäcklin; Mats Gustafsson; Markus Ringnér; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Recent evidence indicate that DNA methylation (DNAm) play a central role in the development and progression of the disease. LÄS MER

  5. 14. Tools for the Advancement of Radiopharmaceutical Therapy

    Författare :Emma Mellhammar; Forskningsgruppen för Systemisk strålterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiopharmaceutical therapy; Nuclear medicine; Monte Carlo simulation; Intratherapeutic preclinical PET; Alpha particles; Beta Particles; radionuclides; Radiobiology; γ-H2AX; Dosimetry;

    Sammanfattning : Radiopharmaceutical therapy is used to treat cancers and other diseases with radiolabeled pharmaceuticals. The treatment targets specific cells, and the emitted ionizing radiation cause cytotoxic damage. Dosimetry is performed to estimate the absorbed dose from the energy deposited in the body. LÄS MER

  7. 15. Identification of protease inhibitors against Flaviviruses and Coronaviruses

    Författare :Dario Akaberi; Åke Lundkvist; Johan Lennerstrand; Josef D. Järhult; Ujjwal Neogi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antiviral research; protease inhibitors; flaviviruses; coronaviruses; ZIKV; TBEV; SARS-CoV-2;

    Sammanfattning : Vector-borne flaviviruses and coronaviruses of zoonotic origins are important human pathogens and represent a serious threat to public health worldwide. Flaviviruses can be found on all continents, apart from Antarctica, where they are transmitted by arthropod vectors causing millions of infections every year. LÄS MER