Sökning: "carrier-mediated transport"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden carrier-mediated transport.

  1. 1. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    Författare :Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. LÄS MER

  3. 2. Membrane transport of triiodothyronine : With particular reference to erythrocytes in health and disease

    Författare :Ann-Charlotte Holm; Nils Nordén; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Cellular T3 uptake was studied in three human cell systems, i.e. cultured lymphocytes, erythrocytes and erythrocyte membrane vesicles. LÄS MER

  4. 3. Intestinal transport of levodopa : Implications for the therapy of Parkinson's disease

    Författare :Dag Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa. duodenal Infusion; intestinal permeability; positron emission tomography; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Levodopa has been the basic treatment of patients with Parkinson's disease for the last 30 years. However, with time nearly all patients develop fluctuations in motor performance correlated to levodopa plasma concentrations. LÄS MER

  5. 4. GABA and human spermatozoa : characterization and regulation of GABA transport proteins

    Författare :Arthur Aanesen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :GABA; spermatozoa; GABA transport; acrosome reaction; sperm motility; progesterone; protein kinase C; GAT-1; GAT-2; GAT-3; BGT-1;

    Sammanfattning : The present project aimed at investigating the interaction between GABA and human spermatozoa under in vitro conditions. Our initial hypothesis was that human spermatozoa had specific binding proteins for GABA and that the binding of GABA to such binding sites could affect sperm function. LÄS MER

  7. 5. Cyclic guanosine 3', 5'-monophosphate : studies on synthesis and efflux from hepatocytes, liver slices and cerebellar slices and on serotonin-mediated cGMP synthesis in human platelets

    Författare :Marie-Louise Tjörnhammar; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The present study established the existence of a carrier mediated transport of 3'5' cGMP from rat liver slices, hepatocytes and cerebellar slices in which the cellular levels of 3'5' cGMP were elevated by application of appropriate stimuli and inhibitors of the 3'5' cyclic nucleotide phosphodiesterase. The carrier is specific for 3'5' cGMP as opposed to 3'5' cAMP. LÄS MER