Sökning: "In-vitro simulations"

Visar resultat 16 - 20 av 57 avhandlingar innehållade orden In-vitro simulations.

  1. 16. Development and Applications of Microfluidic Devices for Liver-on-a-Chip Studies

    Författare :Philip Dalsbecker; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Microfluidics; Microphysiological system; Liver-on-a-Chip; Organ-on-a-chip; Hepatocytes; Induced pluripotent stem cells; iPSC; HepG2; LX-2; on-chip differentiation; PDMS; Microfabrication; Shear stress;

    Sammanfattning : Modeling the human physiology in vitro is a challenging task, yet one of importance for the development of drugs and the study of diseases. To better address the complexities of human organs, microfluidic systems called organs-on-chips are being developed to emulate organ-specific environments for cell culture. LÄS MER

  3. 17. Insights into the small intestinal colloids and their impact on drug solubility

    Författare :Albin Parrow; Christel A.S. Bergström; Per Larsson; Outi Salo-Ahen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Oral administration is the preferred route for drug delivery because it has high patient compliance and is cost effective. The aqueous solubility of modern drug candidates is often poor, but a drug delivered orally must dissolve in the intestine so that it can be absorbed into the circulation. LÄS MER

  4. 18. On Nonlinear Acoustics in Contrast Echocardiography

    Författare :Marcus Ressner; Birgitta Janerot-Sjöberg; Per Ask; Tomas Jansson; Hans Torp; Linköpings universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Ultrasound is one of the most commonly used noninvasive medical imaging techniques. Ultrasound contrast agents (UCA), consisting of encapsulated gas-filled microbubbles, have shown to increase the diagnostic precision in selected low echogenic patients. LÄS MER

  5. 19. Translational Tumor Drug Delivery : Doxorubicin formulation performance, intracellular uptake and molecular diffusion

    Författare :Oliver Degerstedt; Hans Lennernäs; Erik Sjögren; Per Hansson; Jessica Rosenholm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; doxorubicin; drug diffusion; cellular uptake; drug delivery; PBPK modelling; hepatocellular carcinoma; emulsion; IC50; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Globally, hepatocellular carcinoma (HCC) is the most common form of liver cancer and a leading cause of cancer death. One important risk factor is liver cirrhosis and the disease progression is characterized by deposition of extracellular matrix proteins that form a fibrous network, which increases liver stiffness and may limit the effectiveness of different treatment strategies. LÄS MER

  7. 20. Characterisation of brain electrodes for ablative neurosurgery

    Författare :Ola Eriksson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Stereotactic ablative neurosurgery with radio frequency current is regularly performed on patients with movement disorders, for instance Parkinson's disease. Even though the technique has been used for ablation in the brain for almost 50 years, nobody has suggested a standardised way of testing the electrodes used for ablative surgery. LÄS MER