Sökning: "Fibroblast"

Visar resultat 11 - 15 av 268 avhandlingar innehållade ordet Fibroblast.

1. 11. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

   Författare :Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

   Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER

3. 12. Mechanisms of platelet-mediated fibroblast proliferation

   Författare :Cecilia Berg; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Wound healing is a multicomponent event that involves a network of molecular and cellular crosstalk between cells, including leukocytes, platelets and fibroblasts. Despite increased knowledge over the past decades regarding the regulation of cell and tissue growth, the inter- and intracellular systems that control wound healing are incompletely understood. LÄS MER

4. 13. Fibroblast growth factor-induced signal transduction

   Författare :Peter Klint; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Fibroblast growth factors (FGFs) evoke cellular responses by binding to FGF receptors (FGFRs). FGFRs are cell surface expressed membrane-spanning receptors with intrinsic stimulatable tyrosine kinase activity. This thesis describes the cell proliferation or differentiation. LÄS MER

5. 14. The Role of Fibroblast Growth Factor 23 in Phosphate Homeostasis

   Författare :Tobias Erik Martin Larsson; Kenneth Jonsson; Östen Ljunggren; Suzanne Jan De Beur; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Fibroblast Growth Factor 23; FGF-23; phosphate homeostasis; vitamin D metabolism; sodium phosphate cotransporters; autosomal dominant hypophosphatemic rickets; ADHR; X-linked hypophosphatemic rickets; XLH; oncogenic osteomalacia; OOM; PHEX; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : The regulation of serum phosphate (Pi) concentrations is a complex process and our current models are far from complete. Due to major advancements in biotechnology and the development of more powerful research tools, recent advances in the field of genetics has led to the identification of several candidates for the long sought-after phosphatonin(s), or Pi regulating hormones. LÄS MER

7. 15. Fibroblast Contractility in vivo and in vitro : Effects of Prostaglandins and Potential Role for Inner Ear Fluid Homeostasis

   Författare :Anna-Karin Hultgård Ekwall; Kristofer Rubin; Helge Rask-Andersen; Bengt Rippe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Interstitial connective tissue; fibroblasts; prostaglandins; podoplanin; endolymph resorption; Ménière’s disease.; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Fibroblasts continuously strive to organize and compact the surrounding extracellular matrix (ECM). Recent data suggest that this cellular contractility controls interstitial fluid homeostasis in loose connective tissues (CT). LÄS MER