Sökning: "podoplanin"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet podoplanin.

  1. 1. Squamous cell carcinoma of the oral tongue : studies of biomarkers connected to human papillomavirus infection, epithelial to mesenchymal transition and locoregional metastatis

    Författare :Nicola Sgaramella; Karin Nylander; Karin Danielsson; Giuseppe Colella; Robin Fåhraeus; Lorenzo Lo Muzio; George Sekine; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; squamous cell carcinoma oral tongue; p16; HPV; podoplanin; E-cadherin; patologi; Pathology;

    Sammanfattning : Background: Oral Tongue Squamous Cell Carcinoma (OTSCC) is the most frequent and aggressive carcinoma in the head and neck region. Its incidence has increased during the last decades, especially in young patients (≤40 years) mainly female. LÄS MER

  3. 2. Fibroblast Contractility in vivo and in vitro : Effects of Prostaglandins and Potential Role for Inner Ear Fluid Homeostasis

    Författare :Anna-Karin Hultgård Ekwall; Kristofer Rubin; Helge Rask-Andersen; Bengt Rippe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Interstitial connective tissue; fibroblasts; prostaglandins; podoplanin; endolymph resorption; Ménière’s disease.; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Fibroblasts continuously strive to organize and compact the surrounding extracellular matrix (ECM). Recent data suggest that this cellular contractility controls interstitial fluid homeostasis in loose connective tissues (CT). LÄS MER

  4. 3. Kidney Hyaluronan : Regulatory Aspects During Different States of Body Hydration, Nephrogenesis & Diabetes

    Författare :Louise Rügheimer; Peter Hansell; Cecilia Johnsson; Örjan Källskog; Mats Rundgren; Uppsala universitet; []
    Nyckelord :Physiology; hyaluronan; kidney; dehydration; hydration; diabetes; nephrogenesis; renomedullary interstitial cells; CD44; hyaluronan synthase; hyaluronidase; vasopressin; nitric oxide; prostaglandins; glucocorticoids; angiotensin II; diuresis; lymph vessel; podoplanin; Fysiologi;

    Sammanfattning : The kidney regulates the excretion of water and electrolytes, which maintains homeostasis and enables control of arterial blood pressure. Hyaluronan, a large negatively charged interstitial glucosaminoglycan, is heterogeneously distributed within the kidney, primarily found in the medulla. LÄS MER

  5. 4. Biomolecular markers in head and neck cancer

    Författare :Eva Lindell Jonsson; Göran Laurell; Karin Nylander; Marika Nestor; Linda Marklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; Biomolecular markers; Radiation; Radiation-induced mucositis; Oral Tongue Squamous Cell Carcinoma; Metabolomics; EGFR; Hyaluronan; Mast cells; Neutrophils; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Sammanfattning : Head and neck cancer is a heterogeneous group of tumours, of which certain subgroups such as cancer of the mobile tongue frequently are associated with a relatively poor prognosis due to the high risk of regional failure and mortality rates that haven’t improved in a significant way over the last 3 decades, despite advancements in both diagnostics and treatment.Today we lack means to assess the biological aggressiveness of each individual tumour, which varies largely. LÄS MER

  7. 5. Oral leukoplakia, human papillomavirus and cancer transformation : Factors related to human papillomavirus infection and cell proliferation

    Författare :Jonas Sundberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; potentially malignant oral disorders; HPV; recurrence;

    Sammanfattning : Oral leukoplakia (OL) is clinically diagnosed as a white oral lesion that cannot be scraped of or diagnosed as any other type of oral lesion. OL has the potential to transform into oral squamous cell carcinoma (OSCC). The gold standard treatment is a combination of surgical excision if possible, and surveillance. LÄS MER