Sökning: "Single-cell RNA sequencing scRNAseq"

Hittade 4 avhandlingar innehållade orden Single-cell RNA sequencing scRNAseq.

  1. 1. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

    Författare :Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

    Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER

  3. 2. Transcriptomic cellular diversity of the early human developing brain

    Författare :Emelie Paula Braun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The complexity of the mammalian brain is partly reflected in its cell type diversity which influences the function of neurons that encode the behavior of animals. Brain cell type diversity emerges during embryonic stages, a critical period when neurons start to become functionally active and establish their connectivity across the brain. LÄS MER

  4. 3. Kidney diseases : insights from omics approaches

    Författare :Jing Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney diseases (CKDs) affects about 11-15% of adults worldwide. When it progresses to the end-stage renal disease (ESRD), there is no effective medication for cure, the only treatment being chronic dialysis or kidney transplantation. LÄS MER

  5. 4. Identification of genes and pathways involved in the development and progression of glomerular diseases

    Författare :Dina Dabaghie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) affects millions of people worldwide and is characterized by a reduction in glomerular filtration rate and albuminuria resulting in a gradual loss of kidney function. The high prevalence of the disease, along with the limited treatment options available, makes it a major burden to the health care systems around the world. LÄS MER