Sökning: "ErbB2"

Visar resultat 21 - 25 av 26 avhandlingar innehållade ordet ErbB2.

1. 21. Cell cycle alterations and 11q13 amplification in breast cancer : prediction of adjuvant treatment response

   Författare :Marie Ahnström Waltersson; Olle Stål; Marie-Louise Fjällskog; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The growth and development of the breast is to a large extent regulated by oestrogens through the oestrogen receptor (ER). Activation of the ERα triggers transcription of genes that are important for cell proliferation and stimulates entry into the G1 phase of the cell cycle. LÄS MER

3. 22. DNA repair pathways and the effect of radiotherapy in breast cancer

   Författare :Karin Söderlund Leifler; Marie Askmalm Stenmark; Olle Stål; Bo Stenerlöw; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : A large proportion of breast cancer patients are treated with radiotherapy. Ionising radiation induces different DNA damages, of which double-strand breaks are the most severe. They are mainly repaired by homologous recombination or non-homologous end-joining. Different protein complexes have central roles in these repair processes. LÄS MER

4. 23. Improving biomarker assessment in breast pathology

   Författare :Stephanie Robertson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The accuracy of prognostic and therapy-predictive biomarker assessment in breast tumours is crucial for management and therapy decision in patients with breast cancer. In this thesis, biomarkers used in clinical practice with emphasise on Ki67 and HER2 were studied using several methods including immunocytochemistry, in situ hybridisation, gene expression assays and digital image analysis, with the overall aim to improve routine biomarker evaluation and clarify the prognostic potential in early breast cancer. LÄS MER

5. 24. Comprehensive analysis of structural genomic alterations in cancer : Computational approaches for identifying cancer driver events

   Författare :Babak Alaei-Mahabadi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic structural variations; viral integrations; gene fusions; somatic genomic alterations;

   Sammanfattning : The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and size, comprising single nucleotide variants (SNVs), small insertions or deletions (indels), structural variations (SVs) or foreign DNA insertions such as viral DNA. LÄS MER

7. 25. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

   Författare :Fredrik Persson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

   Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER