Sökning: "Epigenetic Regulation"

Visar resultat 16 - 20 av 175 avhandlingar innehållade orden Epigenetic Regulation.

1. 16. CTCF and Epigenetic Regulation of the H19/Igf2 Locus

   Författare :Vinod Pant; Rolf Ohlsson; Rainer Reinkawitz; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; Chromatin; H19; Igf2; CTCF; Insulator; methylation; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : An overall coordination between the expressions of genes is required for the proper development of an individual. Although most genes are expressed from both the constituent alleles of the genome, a small subset of autosomal genes are preferentially expressed from only one of the parental alleles, a phenomenon known as genomic imprinting. LÄS MER

3. 17. Transposable Elements in Neural Progenitor Cells

   Författare :Liana Fasching; Molekylär neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transposable Elements; TRIM28; Epigenetic Regulation; Gene Expression; Neural Progenitor Cells;

   Sammanfattning : More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. LÄS MER

4. 18. Epigenetic Regulation of Higher Order Chromatin Conformations and Gene Transcription

   Författare :Anita Göndör; Reinald Fundele; Thomas Graf; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Genomic imprinting; Chromatin; Epigenetics; Cancer; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : Epigenetic states constitute heritable features of the chromatin to regulate when, where and how genes are expressed in the developing conceptus. A special case of epigenetic regulation, genomic imprinting, is defined as parent of origin-dependent monoallelic expression. LÄS MER

5. 19. Transcriptional and epigenetic control of gene expression in embryo development

   Författare :Ann Boija; Mattias Mannervik; Jerry L. Workman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; Cell specification; Drosophila embryo; Dorsal morphogen; CBP p300; Gene regulation; Chromatin; Promoter proximal Pol II pausing; utvecklingsbiologi; Developmental Biology;

   Sammanfattning : During cell specification, temporal and spatially restricted gene expression programs are set up, forming different cell types and ultimately a multicellular organism. In this thesis, we have studied the molecular mechanisms by which sequence specific transcription factors and coactivators regulate RNA polymerase II (Pol II) transcription to establish specific gene expression programs and what epigenetic patterns that follows. LÄS MER

7. 20. Studies on genetic and epigenetic regulation of gene expression dynamics

   Författare :Leonard Hartmanis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes cellular functional diversity and dysregulation of transcription is a central tenet of human disease. LÄS MER