Sökning: "Epigenetic Regulation"

Visar resultat 11 - 15 av 175 avhandlingar innehållade orden Epigenetic Regulation.

  1. 11. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    Författare :E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. LÄS MER

  3. 12. The return of the nucleus : epigenetic regulation of autophagy

    Författare :Jens Füllgrabe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autophagy is an evolutionary conserved catabolic process activated in response to a variety of cellular stresses, for example nutrient deprivation or chemotherapy. During autophagy, cells engulf parts of their cytplasm in a double-membrane vesicle, where misfolded proteins or damaged organelles are degraded. LÄS MER

  4. 13. Epigenetic regulation of higher order chromatin conformations and networks

    Författare :Chengxi Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Higher order chromatin conformations result from the packaging of the genome into the physical confines of the cell nucleus. Structural hallmarks of the nucleus influence the spatio-temporal behavior of genome underlying the regulation of genomic functions. LÄS MER

  5. 14. Epigenetic gene regulation in multiple myeloma and mood disorders

    Författare :Antonia Kalushkova; Fredrik Öberg; Helena Jernberg-Wiklund; Lucia Cavelier; Anthony Wright; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IKKα; retinoic acid receptor; multiple myeloma; Polycomb; Ouabain; mood disorders;

    Sammanfattning : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. LÄS MER

  7. 15. Epigenetic regulation of gene expression in the vascular endothelium

    Författare :Mia Magnusson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

    Sammanfattning : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. LÄS MER