Sökning: "Deacetylation"

Visar resultat 1 - 5 av 25 avhandlingar innehållade ordet Deacetylation.

  1. 1. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

    Författare :Maria Simonsson; Johan Ericsson; Eva Grönroos; Marikki Laiho; Uppsala universitet; []
    Nyckelord :Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

    Sammanfattning : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. LÄS MER

  3. 2. Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

    Författare :Nina Rosenqvist; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; Neurology; neuropsychology; ChIP; rat; transgene; insulator; differentiation; GFP; lentivirus; DNA methylation; histone deacetylation; chromatin; expression; silencing; stem cell; progenitor; gene therapy; neurofysiologi; neuropsykologi; CNS; transplantation;

    Sammanfattning : The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. LÄS MER

  4. 3. Chemical studies of 0-antigens from Shigella

    Författare :Kurt Petersson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The structure of 13 types of Shigella flexneri O-antigens has been determined, using a N-deacetylation-deamination reaction sequence. The correlation between chemical structures and immunological classification of Shigella flexneri is discussed. LÄS MER

  5. 4. Studies on cell wall recycling and modification in Gram-negative bacteria

    Författare :Michael C. Gilmore; Felipe Cava; Peter A Lind; Teresa Frisan; Jean-François Collet; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptidoglycan recycling; bacterial cell wall; antibiotics; Agrobacterium tumefaciens; Escherichia coli; Legionella pneumophila; mikrobiologi; Microbiology; Biochemistry; biokemi;

    Sammanfattning : The bacterial cell wall is made from peptidoglycan (PG), a heteropolymer which forms a bag-like exoskeleton that envelopes the cell. PG is constantly remodelled during growth and division, and in response to environmental stimuli. LÄS MER

  7. 5. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis

    Författare :Jenny Presto; Lena Kjellén; Gunnar Pejler; Anders Malmström; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Heparan sulfate; N-deacetylase N-sulfotransferase; NDST; EXT1; EXT2; Biosynthesis; Cell- och molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. LÄS MER