Sökning: "Charlotta Dabrosin"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Charlotta Dabrosin.

  1. 1. Effects of sex steroids on normal human breast : studies in vivo using microdialysis and in vitro in cell culture

    Författare :Charlotta Dabrosin; Bo von Schoultz; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Prolonged exposure to sex steroids may constitute a risk factor for the development of breast cancer. The biological mechanisms involved in breast carcinogenesis are not well understood. LÄS MER

  3. 2. Circulating Biomarkers in Patients with Head and Neck Cancer and the Influence of Cigarette Smoking

    Författare :Bengt-Åke Andersson; Nongnit Laytragoon-Lewin; Pierre Åman; Charlotta Dabrosin; Mikael Johansson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Head and neck cancer (HNC) is a collective name for heterogeneous tumors located in the head and neck regions for which smoking, alcohol and human papillomavirus (HPV) are documented risk factors. The survival of HNC patients has only improved marginally during the last decade. LÄS MER

  4. 3. Identification of Tumor Cell- and Stroma Derived Biomarkers of Treatment Response in Head and Neck Cancer

    Författare :Anna Ansell; Karin Roberg; Ann-Charlotte Johansson; Charlotta Dabrosin; Göran Landberg; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Head and neck squamous cell carcinoma (HNSCC) poses a major health problem in the world with approximately 600 000 new cases yearly. Treatment resistance is a major problem within this patient group and despite advances in treatment strategies the overall survival rate has unfortunately not increased. LÄS MER

  5. 4. Angiogenesis regulation in hormone dependent breast- and ovarian cancer

    Författare :Christina Bendrik; Charlotta Dabrosin; Malin Sund; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Angiogenesis is a key event in tumor progression and a rate-limiting step in the establishment of a clinical cancer disease. The net balance of pro- and anti-angiogenesis mediators in the tissue dictates the angiogenic phenotype of a tumor. LÄS MER

  7. 5. Effects of sex steroids and tamoxifen on VEGF in the breast

    Författare :Stina Garvin; Charlotta Dabrosin; Lars Holmgren; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; breast cancer; estradiol; MCF-7; microdialysis; nude mice; progesterone; sVEGFR-1; VEGFR-2; Oncology; Onkologi;

    Sammanfattning : Sex steroid exposure constitutes a risk factor for breast cancer, but little is known about the effects of sex steroids on factors mediating angiogenesis, the development of new blood vessels, in normal and malignant breast tissue. In this thesis we have investigated the effects of estradiol, progesterone, and the nonsteroidal anti-estrogen tamoxifen on vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2) in normal human breast tissue, endothelial cells, and breast cancer. LÄS MER