Sökning: "Biochemistry Molecular Biology"

Visar resultat 1 - 5 av 1406 avhandlingar innehållade orden Biochemistry Molecular Biology.

  1. 1. Prediction of zinc-binding sites in proteins and efficient protein structure description and comparison

    Författare :Nanjiang Shu; Sven Hovmöller; Elisabeth Sauer-Eriksson; Alexander Luybartsev; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; zinc-binding; shape strings; protein structures; secondary structures; machine learning; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; Bioinformatics; Bioinformatik; Structural biology; Strukturbiologi; Biochemistry; biokemi; strukturbiologi; Structural Biology; Molecular Biology; molekylärbiologi;

    Sammanfattning : A large number of proteins require certain metals to stabilize their structures or to function properly. About one third of all proteins in the Protein Data Bank (PDB) contain metals and it is estimated that approximately the same proportion of all proteins are metalloproteins. LÄS MER

  3. 2. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors

    Författare :Bo Xu; Dan Larhammar; Samuel Svensson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuropeptide Y; genome duplication; Evolution; vertebrate; Pharmacology; Modelling; Kinetics; Bioinformatik; Bioinformatics; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. LÄS MER

  4. 3. Effects of adenosine and acetylcholine on the lacrimal gland

    Författare :Stina K. Carlsson; J. Peter Gierow; Sven Tågerud; Darlene Dartt; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lacrimal gland; adenosine; adenosine receptors; signal transduction; exocrine secretion; tear film; dry eye; Sjögren’s syndrome; acetylcholine; mitogen activated protein kinase; p38; Cell biology; Cellbiologi; Ophtalmology; Oftalmologi; Cell and molecular biology; Cell- och molekylärbiologi; Cell biology; Cellbiologi; Molecular biology; Molekylärbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. LÄS MER

  5. 4. Two Types of Fibrils in ATTR Amyloidosis : Implications for Clinical Phenotype and Treatment Outcome

    Författare :Elisabet Ihse; Per Westermark; Per Hammarström; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; transthyretin; familial amyloidotic polyneuropathy; TTRV30M; non-TTRV30M; wild-type; liver transplantation; cardiomyopathy; fibril composition; Biokemi; Biochemistry; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Experimentell patologi; Experimental Pathology; Medical Biochemistry; Medicinsk biokemi; Molecular Biology; Molekylärbiologi; Pathology; Patologi;

    Sammanfattning : Systemic amyloidoses are a group of lethal diseases where proteins aggregate into fibrillar structures, called amyloid fibrils, that deposits throughout the body. Transthyretin (TTR) causes one type of amyloidosis, in which the aggregates mainly infiltrate nervous and cardiac tissue. LÄS MER

  7. 5. Disarming bacteria : a structure-based approach to design an anti-virulence drug against Listeria monocytogenes

    Författare :Melanie Oelker; A. Elisabeth Sauer-Eriksson; Fredrik Almqvist; Karina Persson; Tiziano Tuccinardi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistances; anti-virulence drug; Listeria monocytogenes; virulence regulation; PrfA; structure-based drug design; ring-fused 2-pyridones; allosteric regulation; Biochemistry; biokemi; medicinal chemistry; läkemedelskemi; molekylär cellbiologi; molecular cell biology; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : Antibiotic resistances are one of the biggest threats to global health and if we don’t change our behavior and way of using antibiotics we will end up in a ‘post-antibiotic era’, in which common infections and minor injuries can once kill again and up to 10 million deaths per year may occur by 2050. Therefore, there is a high need for new anti-bacterial drugs, especially of alternatives to existing antibiotics with already described resistances. LÄS MER