Sökning: "450k array"

Hittade 4 avhandlingar innehållade orden 450k array.

  1. 1. Resolving the Genomic Complexity of Pediatric Acute Lymphoblastic Leukemia

    Författare :Yanara Marincevic-Zuniga; Ann-Christine Syvänen; Caroline Heckman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute lymphoblastic leukemia ALL ; 450k array; DNA methylation; RNA-sequencing; linked-read WGS; B-other; fusion gene; chromosomal translocation; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Structural chromosomal rearrangements are a hallmark of ALL and represent key markers for diagnosis, risk stratification and prognosis. LÄS MER

  3. 2. DNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes

    Författare :Alexander Perfilyev; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Methylation; Adipose Tissue; Illumina 450k methylation array; type 2 diabetes;

    Sammanfattning : Type 2 diabetes (T2D) is a common metabolic disease and its prevalence is increasing worldwide. Adipose tissue plays an important role in metabolic processes. Environmental factors may affect metabolic phenotypes and epigenetics may mediate this influence. LÄS MER

  4. 3. Machine Learning Based Analysis of DNA Methylation Patterns in Pediatric Acute Leukemia

    Författare :Christofer Bäcklin; Mats Gustafsson; Markus Ringnér; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Recent evidence indicate that DNA methylation (DNAm) play a central role in the development and progression of the disease. LÄS MER

  5. 4. Epigenetic dysregulation in relation to psychiatric traits in adolescence and adulthood

    Författare :Adrian Desai Boström; Helgi B. Schiöth; Daniel Nätt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; methylome-wide; DNA methylation; hypersexual disorder; microRNA; oxytocin signaling; psychiatry; hsa-miR-4456; microRNA-4456; MIR4456; epigenetic dysregulation; microRNA expression; gene target prediction; epigenetics; suicide; suicide attempt; HPA axis; CRH gene; Epigenetics; Methylation; Adolescent depression; MIR4646; methylome-wide association study; Omega-3; mQTL analysis; GAD1; HDAC3; DAWBA;

    Sammanfattning : Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. LÄS MER