Sökning: "Diabetes - epigenetik"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Diabetes - epigenetik.

  1. 1. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Författare :Anders H Olsson; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Sammanfattning : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. LÄS MER

  3. 2. DNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes

    Författare :Alexander Perfilyev; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Methylation; Adipose Tissue; Illumina 450k methylation array; type 2 diabetes;

    Sammanfattning : Type 2 diabetes (T2D) is a common metabolic disease and its prevalence is increasing worldwide. Adipose tissue plays an important role in metabolic processes. Environmental factors may affect metabolic phenotypes and epigenetics may mediate this influence. LÄS MER

  4. 3. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

    Författare :Tasnim Dayeh; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG-SNP; glucagon secretion; insulin secretion; human pancreatic islets; DNA methylation; Epigenetics;

    Sammanfattning : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. LÄS MER

  5. 4. Study of DNA methylation in human pancreatic islets

    Författare :Elin Hall; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; epigenetics; DNA mehtylation; human pancreatic islets; insulin secretion;

    Sammanfattning : Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. LÄS MER

  7. 5. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Författare :Siri Malmgren; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER