Sökning: "nicholas valerie"
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1. Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
Sammanfattning : The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on nucleic acid integrity and cellular fitness. In addition to DNA repair mechanisms, these metabolic byproducts are kept in check by so-called sanitation or “housekeeping” enzymes, chief among them the NUDIX hydrolase superfamily. LÄS MER
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