Sökning: "mitochondrial cardiomyopathy"

Visar resultat 6 - 10 av 10 avhandlingar innehållade orden mitochondrial cardiomyopathy.

  1. 6. Mitochondria, contractility and Ca2+ handling : cardiac and skeletal muscle adaptations in health and disease

    Författare :Daniel C Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Contractility is a fundamental feature of skeletal and cardiac muscles. An indispensable step in the cellular signal for contraction is a transient elevation in cytoplasmic free [Ca2+] ([Ca2+]i). Both the production of contractile force and Ca2+ handling processes are highly energy demanding. LÄS MER

  3. 7. Role of intermediate filament desmin in development of desmin-related myopathy

    Författare :Natalia Smolina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Desmin is a major intermediate filament of muscle cells, serving to transmit mechanical forces and propagate mechanochemical signals, to coordinate contraction and relaxation cycles, and to stabilize the positioning of cellular organelles, e.g. mitochondria. LÄS MER

  4. 8. Genetic and pathophysiological study of desmin derangements in cardiac disorders

    Författare :Anna Kostareva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Desmin is a chief intermediate filament of skeletal and cardiac muscle. Its main function is to provide structural and functional integrity to the cell and to transmit tension along the myofibrils, protecting them from mechanical stress during contractionrelaxation process. LÄS MER

  5. 9. Gene environment-interaction and cardiovascular phenotype in obesity and diabetes

    Författare :Shafaat Hussain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical modifications of DNA-histone complexes defined epigenetic changes regulate gene expression by modifying chromatin accessibility to transcription factors. LÄS MER

  7. 10. Redox and epigenetic modulators regulate cardiac function and remodeling in health and disease

    Författare :Zaher ElBeck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxidative species are a divergent group of cellular metabolites with a wide variety of functions. Together with reductants, they regulate almost all cellular functions, from mediating cellular communications to catalyzing a variety of biochemical reactions, and further to posttranslationally modifying proteins. LÄS MER