Sökning: "ligase"

Visar resultat 21 - 25 av 115 avhandlingar innehållade ordet ligase.

  1. 21. Unwrapping the role of WRAP53β in DNA damage response

    Författare :Hanif Rassoolzadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). LÄS MER

  3. 22. TRIM21/ Ro52 in B cell pathology

    Författare :Susanna Brauner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell associated genetic polymorphisms. In addition, pSS patients display a 16 fold increased risk to develop B cell lymphomas. LÄS MER

  4. 23. Identification of novel pathways of regulation of AHR and HIF-­1 function

    Författare :Michael Gralla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate the cellular response to physiological signals such as low oxygen levels (hypoxia), or environmental signals such as toxins. LÄS MER

  5. 24. Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia

    Författare :Aditya Harisankar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current treatment options for GBM lack specificity and result in severe side effects. LÄS MER

  7. 25. Studies on the mechanisms of action and physiological relevance of SOCS proteins

    Författare :Fahad Al-Zadjali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Understanding systemic biological pathways and the key cellular mechanisms that dictate disease states, drug response, and altered cellular function in metabolic disorders is a significant challenge. Research in the last 20 years have made it clear that tissue communication, through the actions of endocrine, paracrine or autocrine factors play a significant role in pathogenesis of complex multiorgan diseases such as the metabolic syndrome. LÄS MER