Sökning: "intrinsic pathway"

Visar resultat 6 - 10 av 109 avhandlingar innehållade orden intrinsic pathway.

  1. 6. Integrating extrinsic and intrinsic cues to guide cell fate decisions : rational approaches in stem cell engineering

    Författare :Jamie Mong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The long-term goal of stem cell engineering is to generate functional cells for cell replacement therapies, disease modelling and in drug development assays. It is evident that one of the major challenges in stem cell research is to develop reproducible methods to obtain well-defined and pure populations of clinically relevant cell types in a sustainable manner. LÄS MER

  3. 7. On extrinsic and intrinsic organizational themes in gram negative bacteria and their role in evolution and virulence of the bacterial genus Salmonella spp

    Författare :Anders Folkesson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Salmonella; fimbriae; evolution; cell wall; peptidoglycan;

    Sammanfattning : Gram-negative bacteria are composed of intrinsic organizational themes such as outer and inner membrane, cell wall, and replicons. Themes that not only determine the body-plan and physical properties but also set the boundaries for choice of life style and evolution of the organisms. LÄS MER

  4. 8. Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis

    Författare :Linda Labberton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Blood coagulation leading to fibrin formation is essential to prevent loss of blood (hemostasis), but can also contribute to occlusion of vessels (thrombosis). Thrombosis causes pulmonary embolism, myocardial infarction and stroke, which are together the most common cause of death in the developed world. LÄS MER

  5. 9. Vascular development and safeguard mechanisms against tumorigenesis : oncogene-induced apoptosis and cellular senescence

    Författare :Eduar Hejll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis;

    Sammanfattning : Angiogenesis, apoptosis and senescence are all cellular processes that have an impact on tumor development. Angiogenesis or the new vessel formation from pre-existing ones is known to be required for invasive tumor growth and metastasis. LÄS MER

  7. 10. Towards a comprehensive modeling framework for studying glucose repression in yeast

    Författare :Linnea Österberg; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; budding yeast; glucose repression; metabolism; mathematical modelling; signaling;

    Sammanfattning : The yeast Saccharomyces cerevisiae is an important model organism for human health and for industry applications as a cell factory. For both purposes, it has been an important organism for studying glucose repression. LÄS MER