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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Pain in Osteoarthritic Joints: Biological Signaling and 3D Models based on Imaging

    Författare :Birgitta Gatenholm; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; pain in knee joints; cartilage lesions; micro-computed tomography; 3D CAD models; neuropeptides;

    Sammanfattning : Osteoarthritis (OA) is the most common joint disease, causing disability in middle-aged and elderly patients worldwide and imposing a huge socioeconomic burden. OA of the knee joint is a major cause of joint pain and, along with back pain, it accounts for the two most-reported causes of chronic pain. LÄS MER

  3. 2. Focal knee resurfacing : a translational study in sheep on the treatment of focal condylar cartilage lesions with metal implants

    Författare :Nicolas Martinez-Carranza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The translational process of introducing a new treatment concept in medicine from innovation to clinical application is a challenging endeavour that often involves animal experiments. Focal cartilage lesion remains a clinical challenge and is considered to portend osteoarthritis (OA). LÄS MER

  4. 3. Neurotoxic Effects of Dichlorophenyl Methylsulphones Related to Olfactory Mucosal Lesions

    Författare :Carina Carlsson; Ingvar Brandt; Hans Tjälve; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; olfcatory toxicity; olfactory bulb; aryl methylsulphone; neurotoxicity; QSAR; Biologi; Biology; Biologi; Ecotoxicology; Ekotoxikologi;

    Sammanfattning : This thesis deals with the highly potent olfactory mucosa toxicant 2,6-dichlorophenyl methylsulphone (2,6-diClPh-MeSO2) and its non-toxic 2,5-chlorinated isomer (2,5-diClPh-MeSO2). In mice, both substances bind firmly in the olfactory mucosa and the olfactory bulb, which are important components of the sensory system. LÄS MER

  5. 4. Morphological and molecular changes in developing guinea pig osteoarthritis

    Författare :Harald Brismar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Osteoarthritis (OA) - an unspecific term for late joint destruction-is one of the most common causes of pain and disability in elderly. OA is characterized by destruction of articular cartilage and insufficient tissue repair. Hartley guinea pigs develop a spontaneous knee arthropathy similar to primary human knee OA. LÄS MER

  7. 5. Knee injuries and their consequences – the impact of impact

    Författare :Per Swärd; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Anterior cruciate ligament (ACL) injuries are common, severe knee injuries that result in a high risk of developing knee osteoarthritis (OA) in the affected individuals. As proof of high impact forces applied to cartilage and bone at the time of injury, traumatic bone marrow lesions and osteochondral fractures, located predominantly in the lateral tibiofemoral compartment, are commonly associated with an ACL injury. LÄS MER