Sökning: "bipolar disease"

Visar resultat 11 - 15 av 29 avhandlingar innehållade orden bipolar disease.

1. 11. Genetic association studies of symptoms, comorbidity and outcome in bipolar disorder and schizophrenia

   Författare :Dzana Sudic Hukic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Schizophrenia and bipolar disorder are complex brain disorders. Research has focused on applying brain research to understand the etiology, as well as clinical research to improve treatment, prognosis and progression. LÄS MER

3. 12. Mortality in schizophrenia and affective disorder

   Författare :Urban Ösby; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Schizophrenia; Bipolar disorder; Unipolar disorder; Schizophrenia Incidence; Standardized Mortality Ratio; Schizophrenia Mortality; Bipolar disorder Mortality; Unipolar disorder Mortality; Schizophrenia Suicide; Bipolar disorder Suicide; Unipolar disorder Suicide. Medical Record Linkage; Patient admission; Epidemiology; Registries;

   Sammanfattning : Patients with psychiatric disorders such as schizophrenia, bipolar disorder and unipolar disorder have a considerably increased mortality compared to the population. To reduce this increased mortality is a major task for clinical psychiatry, and the aim of this study is to improve the knowledge about the increased mortality in order to reduce its effects for the patients. LÄS MER

4. 13. Genomic studies of expanded trinucleotide repeats : focus on neuropsychiatric disorders

   Författare :Kerstin Lindblad; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :affective disorder; CTG18.1; DNA; ERDA1; expanded trinucleotide repeats; gene isolation; mutation; Parkinson s disease; repeat expansion detection; repeat instability; spinocerebellar ataxia;

   Sammanfattning : In a number of neurological and neuropsychiatric disorders, a worsening of the disease phenotype from one generation to the next has been linked to expanded trinucleotide repeat sequences that increase in size upon transmission. The clinical phenomenon of an earlier age of onset or a more severe phenotype in later generations of a family has been termed anticipation. LÄS MER

5. 14. The Human Y chromosome and its role in the developing male nervous system

   Författare :Martin M. Johansson; David Skuse; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MSY; sex differences; CNV; SNP; palindrome; palindromes; gr gr duplication; gr gr deletion; b2 b3 deletion; b2 b3 duplication; blue-grey duplication; blue-grey like duplication; IR2; U3; STS; AZFa; AZFb; AZFc; Olivary nucleus; Medulla oblongata; spinal cord; white matter; Affymetrix 6.0; embryo; embryonal; haplogroup; haplogroups; R1a; R1b; R-M207; E-M96; I-M170; J-M304; G-M201; Ashkenazi; Bolivian; Chinese; SNP array; padlock probing; AMY-tree; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

   Sammanfattning : Recent research demonstrated that besides a role in sex determination and male fertility, the Y chromosome is involved in additional functions including prostate cancer, sex-specific effects on the brain and behaviour, graft-versus-host disease, nociception, aggression and autoimmune diseases. The results presented in this thesis include an analysis of sex-biased genes encoded on the X and Y chromosomes of rodents. LÄS MER

7. 15. Risks, correlates, and consequences of the extended psychosis phenotype

   Författare :Martin Cederlöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Psychotic disorders such as schizophrenia entail substantial suffering for the affected individuals and their networks. Traditionally, these disorders come as diagnosable entities that you either have or have not. However, recent epidemiological research has shown that symptoms of psychotic disorder, i.e. LÄS MER