Sökning: "b-AP15"

Visar resultat 11 - 14 av 14 avhandlingar innehållade ordet b-AP15.

  1. 11. Elucidation of thioredoxin reductase 1 as an anticancer drug target

    Författare :William C Stafford; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer constantly finds ways to survive, so we must find new ways to stop it. A major attribute of cancer cells is increased oxidative stress, occurring in the form of reactive oxygen species (ROS). Basal ROS generation commonly occurs in all types of cells and is essential for normal cellular growth and function. LÄS MER

  3. 12. The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?

    Författare :Dhifaf Sarhan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in their targeting of tumors, their responses in the tumor microenvironment have been very challenging to determine. LÄS MER

  4. 13. Molecular mechanisms and targets of new anticancer treatments

    Författare :Amirata Saei Dibavar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies on a recent method called Functional Identification of Target by Expression Proteomics (FITExP) developed in Zubarev lab, where drug induced proteomic signatures are analyzed in various cell lines and top differentially regulated proteins with consistent behavior are determined, among which the drug target and mechanistic proteins are usually present. LÄS MER

  5. 14. Different approaches to develop radio- and chemotherapy for treatment of human cancer

    Författare :Chitralekha Mohanty; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy of several anti-cancer therapies including radiotherapy and chemotherapy would be required to achieve effective treatment. LÄS MER