Sökning: "aquaporin 3"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden aquaporin 3.

1. 16. Role of ion and water channels for lung growth in congenital diaphragmatic hernia

   Författare :Andreas Ringman Uggla; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Early lung development is based on a continuous cross-talk of growth and transcription factors between the developing lung bud and the surrounding parenchyma. Throughout fetal life, pulmonary growth and differentiation depend on Cl- driven lung liquid secretion. LÄS MER

3. 17. Bioengineering and Cell-derived Strategies for Salivary Gland Regeneration

   Författare :Jiao DONG; Lungbioengineering och regeneration; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular vesicles; precision-cut tissue slices; histology scoring; sustainable histology; salivary gland; human dental pulp stem cells; extracellulära vesiklar; stamceller från mänsklig tandmassa; precisionsskurna vävnadsskivor; Spottkörtel; hållbar histologi och histologipoäng;

   Sammanfattning : Xerostomia (dry mouth symptoms) is a group of incurable debilitating conditions of salivary glands caused by aging, radiation/chemical exposure, or aberrant inflammation in the salivary glands. During this PhD thesis, we aimed to evaluate whether cell-derived strategies (e.g. LÄS MER

4. 18. A special role of Na,K-ATPaseand its molecular partners for astrocyte function

   Författare :Nina Illarionova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Astrocytes are glial cells that express several specific transporters and channels with specialized functions to maintain water, ion and neurotransmitter concentrations in order to preserve normal neuronal function. Astrocytes express two catalytic isoforms of plasma membrane enzyme Sodium Potassium-ATPase (Na,K-ATPase), that are essential for several of astrocyte’s functions. LÄS MER

5. 19. Developing a Porcine Model to Study the Glymphatic System

   Författare :Nicholas Bechet; Glia-Immune Interactions; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glymphatic system; cerebrospinal fluid; Porcine; in vivo imaging; amyloid beta; Alzheimer disease;

   Sammanfattning : The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. LÄS MER

7. 20. LXR and aromatase knock-out mice : animal models providing insight into human diseases

   Författare :Hyun-Jin Kim; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. LÄS MER