Sökning: "adrenocortical cells"
Visar resultat 11 - 15 av 21 avhandlingar innehållade orden adrenocortical cells.
11. Interaction of Xenobiotics with the Glucocorticoid Hormone System in vitro
Sammanfattning : Persistent environmental pollutants were examined for their interaction with the glucocorticoid hormone system. The focus was placed on interference with the glucocorticoid synthesis and the glucocorticoid-signalling pathway in various in vitro test systems. LÄS MER
12. The autoimmune regulator : studies of immunological tolerance in mouse and man
Sammanfattning : The aim of the work presented in this thesis was to investigate how failure in the mechanisms that regulate self-tolerance can lead to autoimmune disease. In particular, I have studied a key player in immunological tolerance, the autoimmune regulator gene (AIRE). LÄS MER
13. Differential microRNA and metabolic expressions in neuroendocrine and cervical carcinomas
Sammanfattning : MicroRNAs (miRNAs) are important regulators of many biological processes involved in cancer development and progression. However, the functional roles of miRNAs in some cancer types are still poorly understood. LÄS MER
14. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p´-DDD and DMBA Investigated in Tissue Slice Culture
Sammanfattning : I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed irreversible binding and adrenocorticolytic effects in human, rodent, and fish adrenal tissue, ex vivo. Autoradiography and radioluminography of exposed tissue slices showed that the potent adrenal toxicant 3-methylsulphonyl-2,2´-bis(4-chlorophenyl)-1,1´-dichloroethene (MeSO2-DDE) causes a selective metabolite binding in zona fasciculata (ZF), which is diminished by the CYP11B1 inhibitor metyrapone. LÄS MER
15. Clinical and functional aspects of microRNA regulation in human cancers
Sammanfattning : miRNAs are short single-stranded non-coding RNAs which regulate gene expression at the post-transcriptional level in many biological processes, including proliferation, apoptosis and differentiation. A number of studies have shown the importance of miRNAs in carcinogenesis and accumulating evidence supports their role as diagnostic and prognostic biomarkers in human cancers. LÄS MER