Sökning: "Zheng"

Visar resultat 26 - 30 av 86 avhandlingar innehållade ordet Zheng.

  1. 26. Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors

    Författare :Xinyu Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells and subsequent treatment with ganciclovir is one of the most commonly studied strategies of suicide gene therapy. LÄS MER

  3. 27. Oxygen-dependent regulation of HIF-1alpha expression and function

    Författare :Xiaowei Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. LÄS MER

  4. 28. Regulation of cellular responses to hypoxia by HIF-1alpha-dependent and -independent signaling pathways

    Författare :Xiaofeng Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypoxia is a state of inadequate oxygen supply to the cells and tissues of the body. It plays a critical role in embryonic development, as well as in various physiological and pathological processes. LÄS MER

  5. 29. Development and application of an LC-MS method for the alcohol biomarker phosphatidylethanol (PEth) in blood

    Författare :Yufang Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Objective biomarkers tracing alcohol consumption are demanded in many situations when alcohol drinking is in focus, e.g. during monitoring of patient in a treatment program, in forensic medicine, workplace testing or biochemical validation of self-report in research. LÄS MER

  7. 30. Exploring dual-lipopolysaccharide exposure on schizophrenia-like behavior and the kynurenine pathway in rodent models

    Författare :Yiran Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immune activation contributes to the pathophysiology of schizophrenia. The kynurenine pathway, serving as the primary route of tryptophan catabolism, has been posited as a potential link between immune activation and the manifestation of symptoms associated with schizophrenia. LÄS MER