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Visar resultat 1 - 5 av 86 avhandlingar som matchar ovanstående sökkriterier.
1. Disentangling production and climate signals from high-resolution Beryllium records: implications for solar and geomagnetic reconstructions
Sammanfattning : The sun is the most important energy source for the Earth’s climate system, however, influences of solar variations on climate are not fully understood. Studying past solar activity can improve our understanding of what role the sun plays in Earth’s climate. LÄS MER
2. Regulation of HPV16 Early Gene Expression
Sammanfattning : Human papillomavirus type 16 (HPV16) is the most common high-risk type and isassociated with more than 50% cervical cancer cases as well as a number of headand neck cancer cases. The life cycle of HPV16 is strictly linked to celldifferentiation in the squamous epithelium with expression of the HPV16 earlygenes. LÄS MER
3. How Immigrants Invent : Evidence from Sweden
Sammanfattning : This thesis investigates the inventive performance of immigrants in Sweden based on a special database which links inventors to the general population of the country from 1985 to 2007. It shows that the inventive performance of immigrants is influenced by immigrants’ age at migration, region of origin, educational level, match between education and occupation and migration policy. LÄS MER
4. The origins and consequences of attention deficit hyperactivity disorder
Sammanfattning : Attention deficit hyperactivity disorder (ADHD) is characterized by developmentally inappropriate levels of inattention, hyperactivity, and impulsivity, and is the most common neurodevelopmental disorder of childhood. This highly prevalent disorder is estimated to affect about 5% of school-age children worldwide, with a substantial degree of persistence over time. LÄS MER
5. Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
Sammanfattning : Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA elongation, is silent in most normal differentiated human cells due to the tight repression of its catalytic unit, telomerase reverse transcriptase (hTERT), whereas constitutive hTERT expression and telomerase activation are prerequisites for cellular immortalization/malignant transformation. As reconfiguration of chromatin acts like a master on/off switch, determining whether particular genes are active or inactive, the project was specifically designed to first elucidate molecular strategies that integrate diverse signalling pathways at the hTERT chromatin and consequently result in telomerase activation or repression in normal and malignant human cells. LÄS MER
