Sökning: "THIOUREA"

Visar resultat 11 - 12 av 12 avhandlingar innehållade ordet THIOUREA.

  1. 11. Reactions of Model and Anticancer Active Platinum(IV/II) Complexes - A Kinetic and Mechanistic Study

    Författare :Kelemu Lemma; Kemiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Model Pt II complexes; Anticancer active Pt IV compounds; Cisplatin; Rescue agents; L-Ascorbic acid; Thiol; Substitution; Kinetics and mechanism; Electron transfer; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic acid and substitution reactions of cisplatin and model Pt(II) complexes with S-donor nucleophiles (rescue agents) have been investigated using stopped-flow and UV/VIS spectrophotometry. Glutathione (GSH) reduction of the anticancer active Pt(IV) compounds t- and c-[PtCl4(cha)(NH3)] (cha = cyclohexylamine), t-[PtCl4(thiazole)(NH3)] and c-[PtCl4(NH3)2] at 25 oC was observed to be very fast. LÄS MER

  3. 12. Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention

    Författare :Andreas Ekborn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cisplatin; ototoxicity; pharmacokinetics; monohydrated complex of cisplatin; protection;

    Sammanfattning : Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. LÄS MER