Sökning: "probenecid"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet probenecid.

1. 1. Pharmacokinetics of probenecid with emphasis on its induced accumulation of central monoamine metabolites

   Författare :Britt-Marie Emanuelsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Sammanfattning : .... LÄS MER

3. 2. Furosemide dosage input : consequences for diuretic effect, tolerance and efficiency

   Författare :Monique Wakelkamp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :furosemide; drug input rate; pharmacokinetics; pharmacodynamics; tolerance; efficiency; probenecid;

   Sammanfattning : The development of new dosage forms raises the question of how the pharmacokinetic pharmacodynamic (PK-PD) profile of a drug is influenced by the drug input rate. Furosemide was used as a model drug to study the relationship between drug input rate and effect. LÄS MER

4. 3. Blood-Brain Barrier Transport of Drugs Across Species with the Emphasis on Health, Disease and Modelling

   Författare :Karin Tunblad; Margareta Hammarlund-Udenaes; Niclas Jonsson; Elizabeth CM de Lange; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Blood-brain barrier; Disease; Microdialysis; Modelling; Transport; Pharmacokinetics; NONMEM; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci;

   Sammanfattning : The transport of drugs across the blood-brain barrier (BBB) has been investigated in different species using morphine and morphine-6-glucuronide (M6G) as model compounds. The influence of probenecid on the BBB transport of morphine and M6G was investigated, and the consequences of meningitis and severe brain injury on the concentrations of morphine in the brain were examined. LÄS MER

5. 4. Cyclic guanosine 3', 5'-monophosphate : studies on synthesis and efflux from hepatocytes, liver slices and cerebellar slices and on serotonin-mediated cGMP synthesis in human platelets

   Författare :Marie-Louise Tjörnhammar; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The present study established the existence of a carrier mediated transport of 3'5' cGMP from rat liver slices, hepatocytes and cerebellar slices in which the cellular levels of 3'5' cGMP were elevated by application of appropriate stimuli and inhibitors of the 3'5' cyclic nucleotide phosphodiesterase. The carrier is specific for 3'5' cGMP as opposed to 3'5' cAMP. LÄS MER

7. 5. Distribution of antiviral nucleoside analogues into brain and skin

   Författare :Natalia Borg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The aim of this thesis was to study physiological and physico-chemical factors influencing the pharmacokinetics and distribution over the blood-brain barrier of antiviral nucleoside analogues in the rat, and to study the distribution to the human skin in vivo of an anti-herpetic nucleoside analogue. Microdialysis was used to sample the free (unbound) extracellular concentration of the nucleoside analogues from the brain tissue, muscle and blood in the rat and from the dermis of healthy human volunteers. LÄS MER