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1. 1. The role of the serotonergic system and the effects of antidepressants during brain development examined using in vivo PET imaging and in vitro receptor binding

   Författare :Stal Saurav Shrestha; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Serotonin (5-HT) and the serotonergic system, which includes the serotonin transporter (SERT) and the two G protein-coupled 5-HT1A and 5-HT1B receptors, are implicated in the pathophysiology and treatment of several neuropsychiatric disorders including major depressive disorder (MDD) and anxiety. Two classes of antidepressants—selective serotonin reuptake inhibitors (SSRIs), which block SERT, and tricyclic antidepressants (TCAs), which block several monoamine transporters—alter 5-HT levels and modulate the serotonergic system. LÄS MER